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Merck
CN
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安全信息

PZ0317

Sigma-Aldrich

Capromorelin tartrate

≥98% (HPLC)

别名:

2-Amino-N-[(1R)-2-[(3aR)-2,3,3a,4,6,7-hexahydro-2-methyl-3-oxo-3a-(phenylmethyl)-5H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxo-1-propanamide (2R,3R)-2,3-dihydroxybutanedioate, CP 424391-18, CP-424391 tartrate

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About This Item

经验公式（希尔记法）:
C28H35N5O4 · C4H6O6
CAS号:
193273-69-7
分子量:
655.70
MDL编号:
MFCD25977748
UNSPSC代码:
51111800
PubChem化学物质编号:
329823835
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

H2O: 20 mg/mL, clear

储存温度

room temp

SMILES字符串

O=C1N(C)N=C2CCN(C([C@H](NC(C(C)(C)N)=O)COCC3=CC=CC=C3)=O)C[C@]21CC4=CC=CC=C4.OC([C@H](O)[C@@H](O)C(O)=O)=O

InChI

1S/C28H35N5O4.C4H6O6/c1-27(2,29)25(35)30-22(18-37-17-21-12-8-5-9-13-21)24(34)33-15-14-23-28(19-33,26(36)32(3)31-23)16-20-10-6-4-7-11-20;5-1(3(7)8)2(6)4(9)10/h4-13,22H,14-19,29H2,1-3H3,(H,30,35);1-2,5-6H,(H,7,8)(H,9,10)/t22-,28-;1-,2-/m11/s1

InChI key

MJGRJCMGMFLOET-MYPSAZMDSA-N

一般描述

Capromorelin tartrate has been used in human clinical trials as a treatment for frailty in elderly adults.
Capromorelin tartrate is an agonist of GHSR1a (ghrelin) receptors. It possesses structural homology with pyrazolinone-piperidine dipeptides.

生化/生理作用

Capromorelin tartrate is a potent ghrelin receptor agonist/growth hormone secretagogue (Ki = 7 nM). In rat pituitary cells, Capromorlelin incudes growth hormone (GH) secretion with an EC50 of 3 nM. Capromorelin also increases gastric motility and has been studied recently in patients with spinal cord injuries.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

法规信息

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分析证书(COA)

Lot/Batch Number
0000294214
0000294214
0000155210
0000155210
0000155209

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Practical synthesis of capromorelin, a growth hormone secretagogue, via a crystallization-induced dynamic resolution
Rose C R, et al.
Bioorganic & Medicinal Chemistry, 25(3), 1000-1003 (2017)
Brid Callaghan et al.
British journal of pharmacology, 171(5), 1275-1286 (2014-03-29)
Some agonists of ghrelin receptors cause rapid decreases in BP. The mechanisms by which they cause hypotension and the pharmacology of the receptors are unknown. The effects of ligands of ghrelin receptors were investigated in rats in vivo, on isolated

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