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主要文件

COO原产地证书/COA分析证书

PZ0281

PF-05212384

Name: PF-05212384
Brand: SIGMA

≥98% (HPLC)

别名:

1-(4-((4-(Dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea, Gedatolisib, PKI-587

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About This Item

经验公式（希尔记法）:

C₃₂H₄₁N₉O₄

CAS号:

1197160-78-3

分子量:

615.73

UNSPSC代码:

12352200

NACRES:

NA.77

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Sigma-Aldrich

CBL180-I

CD62E [ELAM-1]抗体，克隆1.2B6

Sigma-Aldrich

324732

ErbB2 Inhibitor II

Sigma-Aldrich

PZ0303

PF-04449913 maleate salt

Sigma-Aldrich

SML1257

KU-0060648

Avanti

792454C

16:0-18:1(n10) PC - IsoPure

Sigma-Aldrich

PZ0147

PHA-665752 水合物

Sigma-Aldrich

494275

氯仿-d

Sigma-Aldrich

A5226

Angiopoietin-1 human

Supelco

1.06067

硫酸镁

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 0.5 mg/mL, clear (warmed)

储存温度

room temp

SMILES字符串

N6(CCOCC6)c1nc(nc(n1)c3ccc(cc3)NC(=O)Nc4ccc(cc4)C(=O)N5CCC(CC5)N(C)C)N2CCOCC2

InChI

1S/C32H41N9O4/c1-38(2)27-11-13-39(14-12-27)29(42)24-5-9-26(10-6-24)34-32(43)33-25-7-3-23(4-8-25)28-35-30(40-15-19-44-20-16-40)37-31(36-28)41-17-21-45-22-18-41/h3-10,27H,11-22H2,1-2H3,(H2,33,34,43)

InChI key

DWZAEMINVBZMHQ-UHFFFAOYSA-N

生化/生理作用

PF-05212384, also known as PKI-587 and Gedatolisib, is a dual phosphatidylinositol-3-kinase (PI3K) / mammalian target of rapamycin (mTOR) inhibitor. PKI-587 potently inhibited class I PI3Ks (IC₅₀ vs PI3K-α = 0.4 nM), PI3K-α mutants, and mTOR. PF-05212384 inhibited growth of 50 diverse human tumor cell lines at IC₅₀s <100 nM and has been in clinical trials in patients with advanced solid tumors. PF-05212384 has also been found to sensitize cells to radiation.