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PZ0280

CP-456773 钠盐

Name: CP-456773 钠盐
Brand: SIGMA

≥98% (HPLC), powder, IL-1β secretion inhibitor

别名:

CRID3, MCC950, N-[[（1，2，3，5，6，7-六氢-s-吲达辛-4-基）氨基]羰基] -4-（1-羟基-1-甲基乙基）-2-呋喃磺酰胺钠盐, 细胞因子释放抑制药物 3

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About This Item

经验公式（希尔记法）:

C₂₀H₂₃N₂NaO₅S

CAS号:

256373-96-3

分子量:

426.46

UNSPSC代码:

51111800

PubChem化学物质编号:

329823808

NACRES:

NA.77

product name

CP-456773 钠盐, ≥98% (HPLC)

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

H₂O: 20 mg/mL, clear

储存温度

room temp

SMILES字符串

CC(O)(C)C1=COC(S([N-]C(NC2=C(CCC3)C3=CC4=C2CCC4)=O)(=O)=O)=C1.[Na+]

InChI

1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1

InChI key

LFQQNXFKPNZRFT-UHFFFAOYSA-M

应用

CP-456773钠盐已用于：

在体内实验中研究生酮饮食的神经保护作用。
研究抑制 NLRP3（nod样受体蛋白3）炎性体活性对小鼠模型肿瘤进展的影响。
研究胆固醇晶体介导的IL-1b（白细胞介素-1b）在胎盘外植体中的反应。

生化/生理作用

CP-456773钠盐（CRID3）是一种细胞因子释放抑制药物，也是NLRP3 炎性体的抑制剂。CP-456773钠盐抑制白细胞介素1β（IL-1β）分泌和caspase 1 加工。

已知 CP-456773抑制其他促炎细胞因子（如IL-1α和IL-18）的释放。它也被称为MCC950。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma.

Chen L, et al.

Cellular and Molecular Life Sciences, 75(11), 2045-2058 (2018)

Efficacy and pharmacology of the NLRP3 inflammasome inhibitor CP-456,773 (CRID3) in murine models of dermal and pulmonary inflammation.

Primiano M J, et al.

Journal of Immunology, 197(6), 2421-2433 (2016)

Ketogenic Diet Improves Brain Ischemic Tolerance and Inhibits NLRP3 Inflammasome Activation by Preventing Drp1-Mediated Mitochondrial Fission and Endoplasmic Reticulum Stress.

Guo M, et al.

Frontiers in Molecular Neuroscience, 11, 86-86 (2018)

Inflammasome-Driven Interleukin-1α and Interleukin-1β Production in Atherosclerotic Plaques Relates to Hyperlipidemia and Plaque Complexity.

Xintong Jiang et al.

JACC. Basic to translational science, 4(3), 304-317 (2019-07-18)

CANTOS (Canakinumab Antiinflammatory Thrombosis Outcome Study) confirmed interleukin (IL)-1β as an appealing therapeutic target for human atherosclerosis and related complications. However, there are serious gaps in our understanding of IL-1 production in atherosclerosis. Herein the authors show that complex plaques

NLRP3 inflammasome activation promotes inflammation-induced carcinogenesis in head and neck squamous cell carcinoma.

Cong-Fa Huang et al.

Journal of experimental & clinical cancer research : CR, 36(1), 116-116 (2017-09-04)

NLRP3 inflammasome acts as a danger signal sensor that triggers and coordinates the inflammatory response. However, the roles of NLRP3 inflammasome in the tumorigenesis and development of cancer stem cells (CSCs) of squamous cell carcinoma of the head and neck

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