PZ0280
CP-456773 钠盐
≥98% (HPLC), powder, IL-1β secretion inhibitor
别名:
CRID3, MCC950, N-[[（1，2，3，5，6，7-六氢-s-吲达辛-4-基）氨基]羰基] -4-（1-羟基-1-甲基乙基）-2-呋喃磺酰胺 钠盐, 细胞因子释放抑制药物 3
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C20H23N2NaO5S
化学文摘社编号:
分子量:
426.46
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
产品名称
CP-456773 钠盐, ≥98% (HPLC)
SMILES string
CC(O)(C)C1=COC(S([N-]C(NC2=C(CCC3)C3=CC4=C2CCC4)=O)(=O)=O)=C1.[Na+]
InChI
1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1
InChI key
LFQQNXFKPNZRFT-UHFFFAOYSA-M
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 20 mg/mL, clear
storage temp.
room temp
Quality Level
Application
CP-456773钠盐已用于：
- 在体内实验中研究生酮饮食的神经保护作用。
- 研究抑制 NLRP3（nod样受体蛋白3）炎性体活性对小鼠模型肿瘤进展的影响。
- 研究胆固醇晶体介导的IL-1b（白细胞介素-1b）在胎盘外植体中的反应。
Biochem/physiol Actions
CP-456773钠盐（CRID3）是一种细胞因子释放抑制药物，也是NLRP3 炎性体的抑制剂。CP-456773钠盐抑制白细胞介素1β（IL-1β）分泌和caspase 1 加工。
已知 CP-456773抑制其他促炎细胞因子（如IL-1α和IL-18）的释放。它也被称为MCC950。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Efficacy and pharmacology of the NLRP3 inflammasome inhibitor CP-456,773 (CRID3) in murine models of dermal and pulmonary inflammation.
Primiano M J, et al.
Journal of Immunology, 197(6), 2421-2433 (2016)
Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma.
Chen L, et al.
Cellular and Molecular Life Sciences, 75(11), 2045-2058 (2018)
Haining Wang et al.
Life sciences, 227, 101-113 (2019-04-20)
NLRP3 inflammasome has been reported associated with some inflammatory and autoimmune diseases. We previously researches showed that interleukin-23 (IL-23) and interleukin-17 (IL-17) aggravates the ischaemic injury of the brain tissue. However, it is poorly understood whether the NLPR3 inflammasome was
Xintong Jiang et al.
JACC. Basic to translational science, 4(3), 304-317 (2019-07-18)
CANTOS (Canakinumab Antiinflammatory Thrombosis Outcome Study) confirmed interleukin (IL)-1β as an appealing therapeutic target for human atherosclerosis and related complications. However, there are serious gaps in our understanding of IL-1 production in atherosclerosis. Herein the authors show that complex plaques
Ketogenic Diet Improves Brain Ischemic Tolerance and Inhibits NLRP3 Inflammasome Activation by Preventing Drp1-Mediated Mitochondrial Fission and Endoplasmic Reticulum Stress.
Guo M, et al.
Frontiers in Molecular Neuroscience, 11, 86-86 (2018)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持