PZ0248
PF-06447475
≥98% (HPLC)
别名:
3-[4-(4-Morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-benzonitrile
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关于此项目
经验公式（希尔记法）:
C17H15N5O
化学文摘社编号:
分子量:
305.33
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
SMILES string
N#CC1=CC=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=C1
InChI
1S/C17H15N5O/c18-9-12-2-1-3-13(8-12)14-10-19-16-15(14)17(21-11-20-16)22-4-6-23-7-5-22/h1-3,8,10-11H,4-7H2,(H,19,20,21)
InChI key
BHTWDJBVZQBRKP-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
room temp
Biochem/physiol Actions
PF-06447475 is a LRRK2 inhibitor.
PF-06447475 is a potent and selective LRRK2 inhibitor.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Antonella Marte et al.
Journal of neurochemistry, 150(3), 264-281 (2019-05-31)
Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain scaffolding protein with kinase and GTPase activities involved in synaptic vesicle (SV) dynamics. While its role in Parkinson's disease has been largely investigated, little is known about LRRK2 physiological role and
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