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主要文件

COO原产地证书/COA分析证书

PZ0245

PF-05105679

Name: PF-05105679
Brand: SIGMA

≥98% (HPLC)

别名:

3-[[[(1R)-1-(4-Fluorophenyl)ethyl](3-quinolinylcarbonyl)amino]methyl]-benzoic acid, PF05105679, [(R)-3-[(1-(4-fluorophenyl)ethyl)(quinolin-3-ylcarbonyl)amino]methylbenzoic acid

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About This Item

经验公式（希尔记法）:

C₂₆H₂₁FN₂O₃

CAS号:

1398583-31-7

分子量:

428.45

UNSPSC代码:

41116158

NACRES:

NA.77

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Sigma-Aldrich

ABT1373M

Anti-Aggrecan

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SML0893

M8-B 盐酸盐

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W0519

WS-12

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C191

辣椒平

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SAB2104241

Anti-TRPM8, (N-terminal) antibody produced in rabbit

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211280

辣椒平

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PZ0412

PF-06427878

Sigma-Aldrich

SML0103

AMTB 水合物

Sigma-Aldrich

M2028

辣椒素

Sigma-Aldrich

N156

Naltriben methanesulfonate hydrate

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 10 mg/mL, clear

储存温度

room temp

生化/生理作用

PF-05105679 is an antagonist of the TRP (transient receptor potential) channel, also known as the cold and menthol receptor 1 (CMR1), with an IC₅₀ value of 103 nM. PF-05105679 is in clinical trials for neuropathic pain. Participants taking PF-05105679 could hold their hands in a bucket of ice water for a long time before feeling pain, and pain-alleviating effects matched those of oxycodone for about one hour after administration.

PF-05105679 is an antagonist of the TRP (transient receptor potential) channel, also known as the cold and menthol receptor 1 (CMR1), with an IC₅₀ value of 103 nM. PF-05105679 is in clinical trials for neuropathic pain. Participants taking PF-05105679 could hold their hands in a bucket of ice water for a long time before feeling pain, and pain-alleviating effects matched those of oxycodone for about one hour after administration.
Transient receptor potential cation channel subfamily M member 8 (TRPM8) antagonist, PF-05105679 [(R)-3-[(1-(4-fluorophenyl)ethyl)(quinolin-3-ylcarbonyl)amino]methylbenzoic acid] acts as a clinical tool to assess the function of TRPM8 in modulating the body temperature. It also helps to determine its role in the treatment of pain in humans.

PF-05105679 is an antagonist of the TRP (transient receptor potential) channel, also known as the cold and menthol receptor 1 (CMR1).