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Merck
CN
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主要文件

PZ0213

Sigma-Aldrich

PF-04418948

≥98% (HPLC)

别名:

1-(4-Fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid

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About This Item

经验公式(希尔记法):
C23H20FNO5
分子量:
409.41
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

储存温度

room temp

SMILES字符串

Fc1ccc(cc1)C(=O)N2CC(C2)(COc3cc4c(cc(cc4)OC)cc3)C(=O)O

InChI

1S/C23H20FNO5/c1-29-19-8-4-17-11-20(9-5-16(17)10-19)30-14-23(22(27)28)12-25(13-23)21(26)15-2-6-18(24)7-3-15/h2-11H,12-14H2,1H3,(H,27,28)

InChI key

LWJGMYMNSNVCEM-UHFFFAOYSA-N

应用

PF-04418948 has been used in TG (trigeminal ganglion) explant culture.

生化/生理作用

PF-04418948 is a PGE2 Receptor (EP2) specific antagonist (IC50 = 16 nM) with greater than 2000-fold selectivity over other EP subtypes. PF-04418948 inhibits EP2 activity in smooth muscle preps from human, dog and mouse.
PF-04418948 represses the formation of colorectal tumor.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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分析证书(COA)

Lot/Batch Number

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访问文档库

Prostaglandin E 2-EP2 signaling as a node of chronic inflammation in the colon tumor microenvironment.
Aoki T and Narumiya S
Inflammation and regeneration, 37(1), 4-4 (2017)
Glial interleukin-1β upregulates neuronal sodium channel 1.7 in trigeminal ganglion contributing to temporomandibular joint inflammatory hypernociception in rats.
Zhang P, et al.
Journal of Neuroinflammation, 15(1), 117-117 (2018)
Eva Mangelsen et al.
Cells, 9(5) (2020-05-23)
Glomerular hyperfiltration is an important mechanism in the development of albuminuria. During hyperfiltration, podocytes are exposed to increased fluid flow shear stress (FFSS) in Bowman's space. Elevated Prostaglandin E2 (PGE2) synthesis and upregulated cyclooxygenase 2 (Cox2) are associated with podocyte
Naoko Komura et al.
Cancer immunology, immunotherapy : CII, 69(12), 2477-2499 (2020-06-21)
The aim of this study was to investigate the role of myeloid-derived suppressor cells (MDSC) in the induction of cancer stem-like cells (CSC) and programmed death ligand 1 (PD-L1) expression in ovarian cancer. CSC were defined as tumor cells expressing

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