PZ0213
PF-04418948
≥98% (HPLC)
别名:
1-(4-Fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid
产品名称
PF-04418948, ≥98% (HPLC)
SMILES string
Fc1ccc(cc1)C(=O)N2CC(C2)(COc3cc4c(cc(cc4)OC)cc3)C(=O)O
InChI
1S/C23H20FNO5/c1-29-19-8-4-17-11-20(9-5-16(17)10-19)30-14-23(22(27)28)12-25(13-23)21(26)15-2-6-18(24)7-3-15/h2-11H,12-14H2,1H3,(H,27,28)
InChI key
LWJGMYMNSNVCEM-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
room temp
Quality Level
Application
PF-04418948 has been used in TG (trigeminal ganglion) explant culture.
Biochem/physiol Actions
PF-04418948 is a PGE2 Receptor (EP2) specific antagonist (IC50 = 16 nM) with greater than 2000-fold selectivity over other EP subtypes. PF-04418948 inhibits EP2 activity in smooth muscle preps from human, dog and mouse.
PF-04418948 is a PGE2 Receptor (EP2) specific antagonist.
PF-04418948 represses the formation of colorectal tumor.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Glial interleukin-1β upregulates neuronal sodium channel 1.7 in trigeminal ganglion contributing to temporomandibular joint inflammatory hypernociception in rats.
Zhang P, et al.
Journal of Neuroinflammation, 15(1), 117-117 (2018)
Prostaglandin E 2-EP2 signaling as a node of chronic inflammation in the colon tumor microenvironment.
Aoki T and Narumiya S
Inflammation and regeneration, 37(1), 4-4 (2017)
Naoko Komura et al.
Cancer immunology, immunotherapy : CII, 69(12), 2477-2499 (2020-06-21)
The aim of this study was to investigate the role of myeloid-derived suppressor cells (MDSC) in the induction of cancer stem-like cells (CSC) and programmed death ligand 1 (PD-L1) expression in ovarian cancer. CSC were defined as tumor cells expressing
Eva Mangelsen et al.
Cells, 9(5) (2020-05-23)
Glomerular hyperfiltration is an important mechanism in the development of albuminuria. During hyperfiltration, podocytes are exposed to increased fluid flow shear stress (FFSS) in Bowman's space. Elevated Prostaglandin E2 (PGE2) synthesis and upregulated cyclooxygenase 2 (Cox2) are associated with podocyte
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