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主要文件

COO原产地证书/COA分析证书

PZ0209

PF-06465469

Name: PF-06465469
Brand: SIGMA

≥97% (HPLC)

别名:

3-[4-Amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-benzamide

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About This Item

经验公式（希尔记法）:

C₃₀H₃₃N₇O₂

CAS号:

1407966-77-1

分子量:

523.63

UNSPSC代码:

12352200

NACRES:

NA.77

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质量水平

100

方案

≥97% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear

储存温度

2-8°C

SMILES字符串

N1(C[C@@H](CCC1)[n]2nc(c5c2ncnc5N)c3cc(ccc3)C(=O)Nc4cc(c(cc4)C(C)C)C)C(=O)C=C

InChI

1S/C30H33N7O2/c1-5-25(38)36-13-7-10-23(16-36)37-29-26(28(31)32-17-33-29)27(35-37)20-8-6-9-21(15-20)30(39)34-22-11-12-24(18(2)3)19(4)14-22/h5-6,8-9,11-12,14-15,17-18,23H,1,7,10,13,16H2,2-4H3,(H,34,39)(H2,31,32,33)/t23-/m1/s1

InChI key

CGJVMKJGKFEHTL-HSZRJFAPSA-N

生化/生理作用

PF-06465469 is a potent, covalent inhibitor of the nonreceptor tyrosine kinase Itk (IL-2 inducible T-cell kinase), which is expressed primarily in immune cells, and is strongly upregulated following activation of T-cells. PF-06465469 inhibits Itk enzymatic activity with an IC₅₀ of 2 nM. The compound blocks anti-CD3 induced phosphorylation of PLCg in Jurkat cells (IC₅₀ = 31 nM) and IL-2 production in anti-CD3 stimulated human whole blood (IC₅₀ = 48 nM).

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.