推荐产品
产品名称
阿西替尼, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to tan
溶解性
DMSO: ≥8 mg/mL
储存温度
room temp
SMILES字符串
CNC(=O)c1ccccc1Sc2ccc3c(\C=C\c4ccccn4)n[nH]c3c2
InChI
1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+
InChI key
RITAVMQDGBJQJZ-FMIVXFBMSA-N
基因信息
human ... FLT1(2321) , FLT4(2324) , KDR(3791)
应用
阿昔替尼已被用作血管内皮生长因子 (VEGF) 受体酪氨酸激酶抑制剂 (TKI) ，以研究其对肾癌细胞体外增殖的影响。此外，在调理水 (CW) 中维持的脱氯胚胎中，它还用于抑制肠系膜上动脉 (AMA) 血管生成。
生化/生理作用
口服有效的选择性 VEGF 受体1、2和3抑制剂
阿昔替尼 (AG-013736) 是一种口服强效（皮摩）选择性酪氨酸激酶抑制剂，可阻断VEGF受体 1、2 和 3。该药物可通过内皮型一氧化氮合成酶、Akt和细胞外信号调节激酶，阻断VEGF介导的内皮细胞存活、血管形成及下游信号传导。
特点和优势
这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
法律信息
根据辉瑞公司的协议出售，用于研究目的。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Ana Carolina Monteiro et al.
Molecular oncology, 13(6), 1433-1449 (2019-05-10)
The high mortality rate of melanoma is broadly associated with its metastatic potential. Tumor cell dissemination is strictly dependent on vascularization; therefore, angiogenesis and lymphangiogenesis play an essential role in metastasis. Hence, a better understanding of the players of tumor
Fatma Demircan Yildirim et al.
Medycyna pracy, 71(6), 649-663 (2020-10-28)
About 8 million healthcare workers in the USA are potentially exposed to hazardous drugs or their toxic metabolites over a long period of time despite the fact that both the Occupational Safety and Health Administration and the European Parliament recommend
Renin expression in developing zebrafish is associated with angiogenesis and requires the Notch pathway and endothelium
Rider S, et al.
American Journal of Physiology: Renal Physiology, 309(6), F531-F539 (2015)
Akira Kazama et al.
Oncology reports, 46(4) (2021-09-02)
The selection of effective therapeutic agents is critical for improving the survival of patients with renal cell carcinoma (RCC). The aim of the present study was to develop an ex vivo drug testing assay using patient‑derived tumor organoid (TO) cultures. For this purpose
Abigail E Descoteaux et al.
Developmental biology, 498, 1-13 (2023-03-23)
The larval skeleton of the sea urchin Lytechinus variegatus is an ideal model system for studying skeletal patterning; however, our understanding of the etiology of skeletal patterning in sea urchin larvae is limited due to the lack of approaches to
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