质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to tan
储存温度
room temp
SMILES字符串
C[C@@H](Oc1cc(cnc1N)-c2cnn(c2)C3CCNCC3)c4c(Cl)ccc(F)c4Cl
InChI
1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
InChI key
KTEIFNKAUNYNJU-GFCCVEGCSA-N
应用
克唑替尼已被用于：
- 研究其对肝细胞生长因子受体（c-Met）表达、增殖和凋亡的影响
- 阻断上皮细胞中神经营养性酪氨酸激酶1型受体（NTRK1）的活性
- 恢复对厄洛替尼的敏感性
生化/生理作用
克唑替尼（PF-02341066）是受体酪氨酸激酶（RTKs）c-Met（肝细胞生长因子受体）和间变性淋巴瘤激酶（ALK）的 ATP 竞争性抑制剂。在 > 120 种研究过的不同的 RTK 中，克唑替尼是一种高度特异性的 c-Met 和 ALK 抑制剂。克里唑蒂尼被批准用于治疗具有 ALK 融合突变的非小细胞肺癌（NSCLC）亚型。
特点和优势
这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
法律信息
根据Pfizer Inc的协议出售，用于研究目的。
警示用语：
Warning
危险分类
Aquatic Acute 1 - Eye Irrit. 2 - Muta. 2 - Skin Sens. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Greenfield E, et al.
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