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Merck
CN

PZ0143

Sigma-Aldrich

PF-4708671

≥98% (HPLC)

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别名:
2-((4-(5-乙基嘧啶-4-基)哌嗪-1-基)甲基)-5-(三氟甲基)-1H-苯并 [d] 咪唑
经验公式(希尔记法):
C19H21F3N6
分子量:
390.41
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

off-white

溶解性

DMSO: ≥20 mg/mL

储存温度

room temp

SMILES字符串

CCC(C=NC=N1)=C1N2CCN(CC3=NC4=C(C=CC(C(F)(F)F)=C4)N3)CC2

InChI

1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26)

InChI key

FBLPQCAQRNSVHB-UHFFFAOYSA-N

基因信息

生化/生理作用

PF-4708671 是一种选择性 p70 核糖体 S6 激酶 (S6K1) 抑制剂。PF-4708671 抑制 S6K1,Ki 为 20 nM,IC 50 为 160 nM,而对密切相关的 RSK 和 MSK 激酶无影响。

特点和优势

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WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Lei Wang et al.
International journal of stem cells, 14(3), 341-350 (2021-04-29)
Approximately 15% of couples suffer from infertility worldwide, and male factors contribute to about 30% of total sterility cases. However, there is little progress in treatments due to the obscured understanding of underlying mechanisms. Recently microRNAs have emerged as a
Erika Ishihara et al.
Genes to cells : devoted to molecular & cellular mechanisms, 25(3), 197-214 (2020-01-29)
Cell competition is a biological process by which unfit cells are eliminated from "cell society." We previously showed that cultured mammalian epithelial Madin-Darby canine kidney (MDCK) cells expressing constitutively active YAP were eliminated by apical extrusion when surrounded by "normal"
Mohamed Moustafa-Kamal et al.
Cell reports, 33(1), 108230-108230 (2020-10-08)
mTOR is a serine/threonine kinase and a master regulator of cell growth and proliferation. Raptor, a scaffolding protein that recruits substrates to mTOR complex 1 (mTORC1), is known to be phosphorylated during mitosis, but the significance of this phosphorylation remains

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