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Merck
CN

PZ0129

Sigma-Aldrich

CP-380736

≥98% (HPLC)

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别名:
6,7-Bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one, 6,7-Bis(2-methoxyethoxy)-4(3H)-quinazolinone, PF-00520893
经验公式(希尔记法):
C14H18N2O5
分子量:
294.30
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

off-white to light tan

溶解性

DMSO: ≥10 mg/mL

储存温度

room temp

SMILES字符串

COCCOc1cc2N=CNC(=O)c2cc1OCCOC

InChI

1S/C14H18N2O5/c1-18-3-5-20-12-7-10-11(15-9-16-14(10)17)8-13(12)21-6-4-19-2/h7-9H,3-6H2,1-2H3,(H,15,16,17)

InChI key

PMQWTUWLIGJTQD-UHFFFAOYSA-N

生化/生理作用

CP-380736 is an inhibitor of the epidermal growth factor receptor (EGFR). EGFR is a tyrosine kinase that activates MAPK, JNK, and Akt pathways, and is an important mediator of several types of cancer, including lung cancer and glioblastoma multiforme.

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Belén Sánchez-Maldonado et al.
Stem cells and development, 27(22), 1557-1576 (2018-09-27)
Cell spheroids are inducible or spontaneously generated cell aggregates produced in vitro that can provide a valuable model for developmental biology, stem cell biology, and cancer therapy research. This investigation aimed to define the cellular identity of spheroids spontaneously generated

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