PZ0124
CP-66713
≥98% (HPLC)
别名:
8-chloro-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-amine, PF-1716311
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关于此项目
经验公式（希尔记法）:
C15H10ClN5
化学文摘社编号:
分子量:
295.73
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
产品名称
CP-66713, ≥98% (HPLC)
InChI
1S/C15H10ClN5/c16-10-6-7-11-12(8-10)21-14(9-4-2-1-3-5-9)19-20-15(21)13(17)18-11/h1-8H,(H2,17,18)
SMILES string
Nc1nc2ccc(Cl)cc2n3c(nnc13)-c4ccccc4
InChI key
PBENJWAFQLORQL-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: ≥5 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
CP-66713 is an adenosine A2 receptor antagonist.
Features and Benefits
This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Y Zhang et al.
European journal of pharmacology, 313(3), 237-242 (1996-10-17)
Propentofylline is an atypical xanthine derivative that blocks adenosine uptake and has been shown to protect against ischemia-induced cerebral damage. We have studied the effect of propentofylline on recruitment of polymorphonuclear leukocytes during acute peritonitis induced by zymosan in mice.
B B Fredholm et al.
European journal of pharmacology, 380(2-3), 197-202 (1999-10-08)
We have examined the potency of several adenosine receptor antagonists at adenosine A1 and A2A receptors using quantitative autoradiography and have compared the results with those of previous studies using the same radioligands in membrane preparations. The agonists [3H]cyclohexyladenosine and
J W Phillis
Brain research, 705(1-2), 79-84 (1995-12-24)
Cerebral ischemia of 5 min duration was induced in unanesthetized Mongolian gerbils by bilateral occlusion of the carotid arteries. The extent of ischemic injury was assessed behaviorally by measuring the increases in locomotor activity following ischemia and by a histopathological
Y Sekino et al.
Biochemical and biophysical research communications, 181(3), 1010-1014 (1991-12-31)
The effects of adenosine A2 receptor antagonist (CP-66713) on long-term potentiation were studied using guinea pig hippocampal slices in a perfusion system. Tetanic stimulation of Schaffer collateral input which was applied during perfusion of CP-66713 (10 microM), did not induce
K A Kirkpatrick et al.
British journal of pharmacology, 110(3), 949-954 (1993-11-01)
1. The effects of A1 and A2a adenosine receptor agonists on the veratridine-evoked release of [3H]-acetylcholine ([3H]-ACh) from rat striatal synaptosomes was investigated by use of the A1-selective agonist, R-PIA and the 185 fold selective A2a agonist, CGS 21680. The
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