所有图片(1)
别名:
6-(2,6-Dichlorophenyl)-8-methyl-2-(4-morpholin-4-ylphenylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, PD-173952
经验公式（希尔记法）:
C24H21Cl2N5O2
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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
yellow to green
溶解性
DMSO: >10 mg/mL
储存温度
2-8°C
SMILES字符串
CN1C(=O)C(=Cc2cnc(Nc3ccc(cc3)N4CCOCC4)nc12)c5c(Cl)cccc5Cl
InChI
1S/C24H21Cl2N5O2/c1-30-22-15(13-18(23(30)32)21-19(25)3-2-4-20(21)26)14-27-24(29-22)28-16-5-7-17(8-6-16)31-9-11-33-12-10-31/h2-8,13-14H,9-12H2,1H3,(H,27,28,29)
InChI key
XZEJMVDCQZRHLN-UHFFFAOYSA-N
生化/生理作用
PD173952 is a Src family kinase inhibitor.
特点和优势
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Alexander Rohe et al.
Bioorganic & medicinal chemistry, 23(15), 4936-4942 (2015-06-11)
Myt1 kinase is a member of the Wee-kinase family involved in G2/M checkpoint regulation of the cell cycle. So far, no peptide substrate suitable for activity-based screening has been reported, hampering systematic development of Myt1 kinase inhibitors. Myt1 inhibitors had
商品
Src is the original member of a group of non-receptor protein-tyrosine kinases termed the Src family kinases (SFKs). Learn about the SFKs that, in humans, consist of eight members, a small group of atypical members, and two related kinases.
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