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Merck
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安全信息

PZ0021

Sigma-Aldrich

Tigecycline hydrate

≥98% (HPLC)

别名:

9-t-Butylglycylamido-minocycline hydrate, TBG-MINO, Tigecyclin, Tygacil

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About This Item

经验公式（希尔记法）:
C29H39N5O8 · xH2O
CAS号:
1229002-07-6
分子量:
585.65 (anhydrous basis)
UNSPSC代码:
12352200
PubChem化学物质编号:
329823688
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

旋光性

[α]/D -175 to -205°, c = 0.15 in methanol

颜色

off-white to yellow-brown

溶解性

DMSO: ≥3 mg/mL (warmed)

储存温度

2-8°C

SMILES字符串

O.CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4c(cc(NC(=O)CNC(C)(C)C)c(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)N(C)C

InChI

1S/C29H39N5O8.H2O/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36;/h10,12,14,21,31,36,38-39,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35);1H2/t12-,14-,21-,29-;/m0./s1

InChI key

PMPLAEFBZIFHAR-KXLOKULZSA-N

一般描述

Tigecycline is used to treat complicated skin and skin structure infections (cSSSI) and complicated intraabdominal infections.

应用

TIGECYCLINE HYDRATE has been used:
  • for antibiotic susceptibility testing
  • to study its effects on multiple nonsmall cell lung cancer (NSCLC) cell lines
  • to evaluate its effects on the binding of fluoroquinolones to human serum albumin
  • as a standard to investigate the penetration of tigecycline into cornea, aqueous humor and vitreous humor

生化/生理作用

Tigecycline is a broad spectrum glycylcycline antibiotic.
Tigecycline is a broad spectrum glycylcycline antibiotic. Tigecycline is bacteriostatic, that inhibits protein synthesis by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline is active against resistant strains of gram-positive and gram-negative bacteria, avoiding the two most common mechanisms of resistance to the tetracycline antimicrobials: tetracycline efflux pump proteins and ribosomal protection proteins.

其他说明

air sensitive

警示用语：

Danger

危险分类

Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Repr. 1B - Skin Sens. 1

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000321754
0000321754
0000269497
0000269500
0000269500

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In vitro activity of tigecycline against isolates from patients enrolled in phase 3 clinical trials of treatment for complicated skin and skin-structure infections and complicated intra-abdominal infections
Bradford PA, et al.
Clinical Infectious Diseases, 41 (2005)
Ocular penetration of topically applied 1% tigecycline in a rabbit model
Sakarya Y, et al.
International journal of ophthalmology, 10(5), 679-679 (2017)
Yasar Sakarya et al.
International journal of ophthalmology, 10(5), 679-683 (2017-05-27)
To evaluate ocular penetration of topically applied 1% tigecycline. Forty-two New Zealand White rabbits were divided into 3 groups. A 50 µL drop of 1% tigecycline was administered in group 1. In groups 2 and 3, the drop was administered
Tigecycline targets nonsmall cell lung cancer through inhibition of mitochondrial function
Jia X, et al.
Fundamental & Clinical Pharmacology, 30(4), 297-306 (2016)
A Jasiecka-Mikołajczyk et al.
Journal of veterinary pharmacology and therapeutics, 41(1), e22-e29 (2017-08-24)
The aim of this research had been to determine the pharmacokinetics of tigecycline (TIG) in turkey after intravenous (i.v.), intramuscular (i.m.), subcutaneous (s.c.), and oral (p.o.) administration at a dose of 10 mg/kg. TIG concentrations in plasma were determined using high-performance
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