推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 15 mg/mL, clear
运输
wet ice
储存温度
−20°C
SMILES字符串
[N+H]5(CCCCCC5)CCOc1ccc(cc1)C[n]2c3c(c(c2c4ccc(cc4)O)C)cc(cc3)O.[O-]C(=O)C
InChI
1S/C30H34N2O3.C2H4O2/c1-22-28-20-26(34)12-15-29(28)32(30(22)24-8-10-25(33)11-9-24)21-23-6-13-27(14-7-23)35-19-18-31-16-4-2-3-5-17-31;1-2(3)4/h6-15,20,33-34H,2-5,16-19,21H2,1H3;1H3,(H,3,4)
InChI key
OMZAMQFQZMUNTP-UHFFFAOYSA-N
应用
醋酸巴泽多昔芬已被用于研究其在抑制白介素6（IL-6）/IL-6R/糖蛋白130途径中的功效，及其对髓母细胞瘤细胞的作用。
生化/生理作用
苯卓昔芬属于第三代非甾体选择性雌激素受体调节剂（SERM），在临床上用于治疗绝经后骨质疏松。苯卓昔芬可以IC50 = 26 nM与雌激素受体-α结合，这与雷洛昔芬相似，但低于17-β雌二醇的亲和力。 苯卓昔芬并不能刺激MCF-7细胞的增殖，反而会以IC50 = 0.19 nM抑制17β -雌二醇诱导的增殖，表现出了理想的激动剂/拮抗剂活性。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Blocking interleukin-6 signaling inhibits cell viability/proliferation, glycolysis, and colony forming activity of human medulloblastoma cells
Xiang Chen
International Journal of Oncology (2018)
Blanca D López-Ayllón et al.
Frontiers in immunology, 14, 1220306-1220306 (2023-08-07)
SARS-CoV-2, the cause of the COVID-19 pandemic, possesses eleven accessory proteins encoded in its genome. Their roles during infection are still not completely understood. In this study, transcriptomics analysis revealed that both WNT5A and IL11 were significantly up-regulated in A549
Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment.
Yanan Chen et al.
eLife, 10 (2021-03-24)
The inflammatory environment of demyelinated lesions in multiple sclerosis (MS) patients contributes to remyelination failure. Inflammation activates a cytoprotective pathway, the integrated stress response (ISR), but it remains unclear whether enhancing the ISR can improve remyelination in an inflammatory environment.
Adam T Szafran et al.
iScience, 25(10), 105200-105200 (2022-10-15)
The United States Environmental Protection Agency (EPA) has been pursuing new high throughput in vitro assays to characterize endocrine disrupting chemicals (EDCs) that interact with estrogen receptor signaling. We characterize two new PRL-HeLa cell models expressing either inducible C-terminal (iGFP-ER) or
Xiang Chen et al.
International journal of oncology, 52(2), 571-578 (2017-12-06)
Elevated levels of the pro-inflammatory cytokine interleukin-6 (IL‑6) have tumor-promoting activity and are associated with poor survival outcomes in many cancers. Additionally, the IL‑6/GP130/STAT3 axis has been widely studied due to its pivotal role in tumor development and maintenance in
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