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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to off-white
溶解性
DMSO: ≥2 mg/mL
储存温度
2-8°C
SMILES字符串
CC1=C(O)C=CC=C1C(N[C@@H](CSC2=CC=CC=C2)[C@H](O)CN3[C@H](C(NC(C)(C)C)=O)C[C@@]4([H])[C@@](CCCC4)([H])C3)=O.[CH2]S(O)(=O)=O
InChI
1S/C32H45N3O4S.CH4O3S/c1-21-25(15-10-16-28(21)36)30(38)33-26(20-40-24-13-6-5-7-14-24)29(37)19-35-18-23-12-9-8-11-22(23)17-27(35)31(39)34-32(2,3)4;1-5(2,3)4/h5-7,10,13-16,22-23,26-27,29,36-37H,8-9,11-12,17-20H2,1-4H3,(H,33,38)(H,34,39);1H3,(H,2,3,4)/t22-,23+,26-,27-,29+;/m0./s1
InChI key
NQHXCOAXSHGTIA-SKXNDZRYSA-N
应用
水合甲磺奈非那韦已用于测试其对系统性硬化症 (Ssc) 患者肺纤维化的治疗效果。此外,它还曾与硼替佐米联用,以选择性杀死结节性硬化症复合物 2 (TSC2)缺陷的肿瘤细胞。
生化/生理作用
水合甲磺奈非那韦又称 AG1343,用作获得性免疫缺陷综合症 (AIDS) 的治疗药剂。它可发挥抗纤维化剂的作用,用于治疗系统性硬化症 (Ssc) 患者的肺纤维化。此外,水合甲磺奈非那韦还可通过激活蛋白磷酸酶 2 (PP-2) 并阻断巨噬细胞中的促分裂原活化蛋白激酶 (MAPK) 信号传导,减轻炎症作用。与此同时,它还可刺激自噬,从而表现出抑癌特性。
奈非那韦是一种HIV蛋白酶抑制剂、抗逆转录病毒和抗肿瘤剂。
特点和优势
这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
The New England journal of medicine, 366(25), 2368-2379 (2012-06-22)
The safety and efficacy of adding antiretroviral drugs to standard zidovudine prophylaxis in infants of mothers with human immunodeficiency virus (HIV) infection who did not receive antenatal antiretroviral therapy (ART) because of late identification are unclear. We evaluated three ART
The Antiretroviral Agent Nelfinavir Mesylate: A Potential Therapy for Systemic Sclerosis
Arthritis & Rheumatology (Hoboken, N.J.), 70(1), 115-126 (2018)
Journal of the National Cancer Institute, 104(20), 1576-1590 (2012-10-09)
Human epidermal growth factor receptor 2 (HER2)-positive breast cancer is highly aggressive and has higher risk of recurrence than HER2-negative cancer. With few treatment options available, new drug targets specific for HER2-positive breast cancer are needed. We conducted a pharmacological
Cancer letters, 325(1), 63-71 (2012-06-06)
The cellular processes of autophagy and endoplasmic reticulum stress (ERS) appear to be interconnected, and it has been proposed that autophagy may serve to reduce ERS via removal of terminally misfolded and aggregated proteins. Conversely, there are indications that blockage
Molecules (Basel, Switzerland), 17(1), 688-702 (2012-01-14)
β-Carotene supplements are often taken by individuals living with HIV-1. Contradictory results from in vitro studies suggest that β-carotene may inhibit or induce cytochrome P450 enzymes and transporters. The study objective was to investigate the effect of β-carotene on the
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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