所有图片(1)
别名:
2R，3S-2-（2,4-二氟苯基）-3-（5-氟嘧啶-4-基）-1-（1H-1,2,4-三唑-1-基）丁-2-醇, UK-109496
经验公式（希尔记法）:
C16H14F3N5O
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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white
溶解性
DMSO: >20 mg/mL
储存温度
room temp
SMILES字符串
C[C@@H](c1ncncc1F)[C@](O)(Cn2cncn2)c3ccc(F)cc3F
InChI
1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1
InChI key
BCEHBSKCWLPMDN-MGPLVRAMSA-N
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一般描述
Voriconazole is a triazole and a synthetic derivative of fluconazole.
应用
Voriconazole has been used:
- as a control and Erg11 inhibitor in YPD medium
- as a reference drug to test the activity of essential oils against clinical strains of Candida sp.
- as an antifungal agent to test its interactions with valproic acid (VPA)
- to compare its in vitro antifungal activity with essential oils and its components against Cryptococcus neoformans azole-susceptible and not-susceptible clinical isolates
生化/生理作用
伏立康唑是用于治疗严重真菌感染的抗真菌药。伏立康唑通过抑制 CYP450 依赖性 14-α甾醇脱甲基酶来抑制麦角固醇合成，从而导致真菌细胞膜中的麦角固醇减少。
Voriconazole is used to treat invasive aspergillosis (IA). It is vigorous against Candida species, including the strains of Candida albicans, which shows resistance to fluconazole.
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 2 - Muta. 2 - Repr. 2 - STOT RE 1 - STOT RE 2 Oral - STOT SE 2 Oral
靶器官
Eyes, Liver,Kidney
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
pH-dependant antifungal activity of valproic acid against the human fungal pathogen Candida albicans
Chaillot J, et al.
Frontiers in Microbiology, 8, 1956-1956 (2017)
Identification and evaluation of novel acetolactate synthase inhibitors as antifungal agents
Richie D L, et al.
Antimicrobial agents and chemotherapy, 57(5), 2272-2280 (2013)
Voriconazole: a new triazole antifungal agent
Saravolatz L D, et al.
Clinical Infectious Diseases, 36(5), 630-637 (2003)
Narcisa Mandras et al.
Molecules (Basel, Switzerland), 26(16) (2021-08-28)
The epidemiology of yeast infections and resistance to available antifungal drugs are rapidly increasing, and non-albicans Candida species and rare yeast species are increasingly emerging as major opportunistic pathogens. In order to identify new strategies to counter the threat of
Use of Pinus sylvestris L.(Pinaceae), Origanum vulgare L.(Lamiaceae), and Thymus vulgaris L.(Lamiaceae) essential oils and their main components to enhance itraconazole activity against azole susceptible/not-susceptible Cryptococcus neoformans strains
Scalas D, et al.
BMC Complementary and Alternative Medicine, 18(1), 143-143 (2018)
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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