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Merck
CN

PZ0002

Sigma-Aldrich

马拉韦罗

≥98% (HPLC)

别名:

4,4-二氟-N-[(1S)-3-[(3-外)-3-[3-甲基-5-(1-甲基乙基)-4H-1,2,4-三唑-4-基]-8-氮杂双环 [3.2.1] 辛-8-基]-1-苯基丙基] 环己甲酰胺, UK-427857

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About This Item

经验公式(希尔记法):
C29H41F2N5O
分子量:
513.67
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

旋光性

[α]-15/D

颜色

white

溶解性

DMSO: >30 mg/mL

储存温度

room temp

SMILES字符串

CC(C)c1nnc(C)n1[C@H]2C[C@@H]3CC[C@H](C2)N3CC[C@H](NC(=O)C4CCC(F)(F)CC4)c5ccccc5

InChI

1S/C29H41F2N5O/c1-19(2)27-34-33-20(3)36(27)25-17-23-9-10-24(18-25)35(23)16-13-26(21-7-5-4-6-8-21)32-28(37)22-11-14-29(30,31)15-12-22/h4-8,19,22-26H,9-18H2,1-3H3,(H,32,37)/t23-,24+,25-,26-/m0/s1

InChI key

GSNHKUDZZFZSJB-QYOOZWMWSA-N

基因信息

human ... CCR5(1234)

应用

马拉韦罗用作小鼠单核细胞/巨噬细胞系J774A.1、猪子宫腔上皮细胞和人肺CD4+ T细胞中的C-C趋化因子受体5型(CCR5特异性)抑制剂。

生化/生理作用

马拉韦罗是一种 CCR5 趋化因子受体拮抗剂和抗逆转录病毒条目抑制剂。马拉韦罗通过阻断病毒外壳蛋白 gp120 与受体的相互作用而抑制 HIV 条目
马拉韦罗通过细胞色素P450 3A4代谢。马拉韦罗在肠道和胆汁中的转运和吸收受p-糖蛋白(Pgp)的调控。马拉韦罗与趋化因子受体CCR5的活性部位组织结合,使受体失去活性。

特点和优势

《受体分类和信号转导》手册的 趋化因子受体页有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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访问文档库

Juan G Sierra-Madero et al.
The lancet. HIV, 1(2), e60-e67 (2015-10-02)
Immune reconstitution inflammatory syndrome (IRIS) is a common complication of antiretroviral therapy (ART) in patients with HIV. IRIS is associated with an increased risk of admission to hospital and death. We assessed whether CCR5 blockade with maraviroc reduces the risk
Assessment of the absorption, metabolism and absolute bioavailability of maraviroc in healthy male subjects
Abel S, et al.
British Journal of Clinical Pharmacology, 65, 60-67 (2008)
Procoagulant and proinflammatory effects of red blood cells on lipopolysaccharide-stimulated monocytes
Osterud B, et al.
Journal of Thrombosis and Haemostasis, 13(9), 1676-1682 (2015)
Laura Pérez-Martínez et al.
The Journal of antimicrobial chemotherapy, 69(7), 1903-1910 (2014-03-22)
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the general population. The NAFLD spectrum ranges from simple steatosis to cirrhosis. The chemokine CCL5/RANTES plays an important role in the progression of hepatic inflammation
HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis
Corleis B, et al.
Testing, 26(6), 1409-1418 (2019)

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