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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
predicted mol wt 54 kDa
种属反应性
mouse, human
技术
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... STEAP2(261729)
一般描述
The Six-transmembrane epithelial antigen of prostate 2 (STEAP2) is a metalloreductase that belongs to the STEAP family. It is localized in secretory and endocytic pathway organelles. The STEAP2 gene is mapped to human chromosome 7q21.13.
免疫原
a 16 amino acid peptide from near the carboxy-terminus of human STEAP2.
生化/生理作用
The Six-transmembrane epithelial antigen of prostate 2 (STEAP2) being localized in Golgi membrane and cytoplasmic vesicles, may have a critical role in the endocytic pathway. It is highly expressed in prostate carcinomas (PCa) and promotes tumor invasion and migration. Along with STEAP3 and 4, STEAP2 levels are implicated in favoring copper and iron uptake. Studies on targeted STEAP2 knockdown have reported a reduction in PCa progression.
联系
The action of this antibody can be blocked using blocking peptide SBP4307.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Shadia M Ihlaseh-Catalano et al.
Histopathology, 63(5), 678-685 (2013-09-13)
To investigate the prognostic value of expression levels of the genes STEAP1 and STEAP2, and of STEAP1 protein, in prostate carcinomas (PCa). STEAP1 and STEAP2 transcript levels were evaluated by RT-qPCR in samples from 35 PCa, 24 adjacent non-neoplastic prostate
Stephanie E A Burnell et al.
Scientific reports, 8(1), 6252-6252 (2018-04-21)
Six-transmembrane epithelial antigen of the prostate-2 (STEAP2) expression is increased in prostate cancer when compared to normal prostate, suggesting STEAP2 may drive prostate cancer progression. This study aimed to establish the functional role of STEAP2 in prostate tumourigenesis and evaluate
Haruki Hasegawa et al.
Experimental cell research, 370(2), 208-226 (2018-06-26)
STEAP2 is a member of the Six-Transmembrane Epithelial Antigen of the Prostate (STEAP) protein family that is proposed to function as metalloreductase. While STEAP2 shows a complex subcellular distribution pattern localizing to both secretory and endocytic pathway organelles, how such
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