生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
mouse, rat, human
技术
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... DDX58(23586)
一般描述
RIG-1 (retinoic acid-inducible gene I) is a cytoplasmic viral RNA receptor, that is also known as DDX58 (DExD/H-box helicase 58). It belongs to RIG-I-like receptor (RLR) family. It has 2 N-terminal caspase recruitment domains (CARDs), a central RNA helicase domain, and a C-terminal RNA-binding domain. It is located on chromosome 9p21.1.
免疫原
human GST-tagged RIG-1 protein.
生化/生理作用
DDX58 (DExD/H-box helicase 58) mutations leads to atypical singleton-merten syndrome. It participates in immune regulation and activation of astrocyte.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Mutations in DDX58, which encodes RIG-I, cause atypical Singleton-Merten syndrome
Jang MA, et al.
American Journal of Human Genetics, 96(2), 266-274 (2015)
Structural features of influenza A virus panhandle RNA enabling the activation of RIG-I independently of 5'-triphosphate
Lee MK, et al.
Nucleic Acids Research, 44(17), 8407-8416 (2016)
MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis
MacNair L, et al.
Brain, 139(Pt 1), 86-100 (2016)
Maurizio Callari et al.
Molecular oncology, 8(7), 1278-1289 (2014-05-24)
The majority of gene expression signatures developed to predict the likelihood to relapse in breast cancer (BC) patients assigns a high risk score to patients with Estrogen Receptor (ER) negative or highly proliferating tumors. We aimed to identify a signature
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