生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
predicted mol wt 39 kDa
种属反应性
rat, human, mouse
技术
indirect ELISA: suitable
western blot: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CCNO(10309)
一般描述
UNG2 (uracil-DNA glycosylase) is a multifunctional glycosylase,that is located in the nucleus. It is also known as CCNO (cyclin O)and is located on chromosome 5q11. It is present in the apical cytoplasm of multiciliated cells.
免疫原
a 14 amino acid peptide from near the amino-terminus of human UNG2.
生化/生理作用
CCNO (cyclin O) is responsible for the differentiation of multiciliated cell. It participates in the cell cycle and DNA repair. CCNO mutations cause congenital mucociliary clearance disorder. It is considered as an important enzyme in base excision repair (BER).
联系
The action of this antibody can be blocked using blocking peptide SBP3859.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Julia Wallmeier et al.
Nature genetics, 46(6), 646-651 (2014-04-22)
Using a whole-exome sequencing strategy, we identified recessive CCNO (encoding cyclin O) mutations in 16 individuals suffering from chronic destructive lung disease due to insufficient airway clearance. Respiratory epithelial cells showed a marked reduction in the number of multiple motile
Cell cycle gene expression networks discovered using systems biology: Significance in carcinogenesis
Scott RE, et al.
Journal of Cellular Physiology, 230(10), 2533-2542 (2015)
Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA
Mer G, et al.
Cell, 103(3), 449-456 (2000)
Vpr-mediated incorporation of UNG2 into HIV-1 particles is required to modulate the virus mutation rate and for replication in macrophages
Chen R, et al.
The Journal of Biological Chemistry, 279(27), 28419-28425 (2004)
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA
Hagen L, et al.
The Embo Journal, 27(1), 51-61 (2008)
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