推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
predicted mol wt 55 kDa
种属反应性
mouse, human
技术
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... XIAP(331)
一般描述
XIAP (X-linked inhibitor of apoptosis protein) belongs to the inhibitor of apoptosis (IAP) family. It is located on chromosome Xq25.
免疫原
a synthetic peptide corresponding to 13 amino acids at the C-terminus of human XIAP.
应用
Anti-XIAP has been used in immunohistochemistry {16,17}.
生化/生理作用
XIAP (X-linked inhibitor of apoptosis protein) modulates several cellular processes like TGF-β (transforming growth factor β) signaling, NF-κB (nuclear factor-κB) pathway, autophagy and inflammatory responses. XIAP mutations are associated with X-linked lymphoproliferative syndrome type 2 (XLP-2).
联系
The action of this antibody can be blocked using blocking peptide SBP3331.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Distinct 5' UTRs regulate XIAP expression under normal growth conditions and during cellular stress
Riley A, et al.
Nucleic Acids Research, 38(14), 4665-4674 (2010)
Zhuan Zhou et al.
EBioMedicine, 15, 48-61 (2017-01-04)
The emerging regulatory role of deubiquitinases (DUBs) has been implicated in various fundamental processes and pathogenesis. To determine the pivotal role that DUBs play in mediating tumorigenesis, we have performed a non-biased screen of 67 human DUBs based on a
Yiping Zhang et al.
OncoTargets and therapy, 11, 8751-8759 (2018-12-26)
Carboplatin is a first-line treatment for ovarian cancer. However, most patients develop resistance and undergo disease recurrence. This study aims to explore the relationship between the expression of X-linked inhibitor of apoptosis protein (XIAP) and carboplatin sensitivity in ovarian cancer.
Chao Chen et al.
Oncology letters, 15(1), 821-832 (2018-02-07)
The X-linked inhibitor of apoptosis protein (XIAP) is the best characterized member of the IAP family and is a potent inhibitor of the caspase/apoptosis pathway. It has also been revealed that XIAP has additional biological functions that rely on its
Dilys T H Leung et al.
Molecular cancer therapeutics, 18(2), 364-375 (2018-12-12)
Ovarian granulosa cell tumors (GCT) are characterized by indolent growth and late relapse. No therapeutic modalities aside from surgery have proven effective. We previously reported overexpression of the nuclear receptor, peroxisome proliferator-activated receptor-gamma (PPARγ), and constitutive activity of the NFκB
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