生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
predicted mol wt 92 kDa
种属反应性
human
技术
immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TLR4(7099)
一般描述
Toll样受体（TLR）是在免疫细胞和非免疫细胞表面表达的跨膜受体。至少有13种不同的TLR已被鉴定出可在组织损伤和细菌感染过程中介导导致急性炎症过程的信号通路。 TLR2可被多种炎症介质因子高度诱导，从而导致转录因子NF-κB介导的促炎细胞因子的移位以及免疫反应
免疫原
对应于人TLR4近氨基端15个氨基酸的一段肽。
联系
可以使用阻断肽 SBP3141阻断该抗体的作用。
外形
溶剂为含有0.02％叠氮化钠的磷酸盐缓冲盐水
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Toll-like Receptor 4 Modulation as a Strategy to Treat Sepsis
Wittebole X et al
Mediators of Inflammation, doi: 10-doi: 10 (2010)
Amanda Croasdell et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30(9), 3181-3193 (2016-06-04)
TLRs are critical for innate immunity, but excessive activation can lead to tissue damage and disease. Specialized proresolving mediators (SPMs), including resolvin D2 (RvD2), promote the active resolution of inflammation. How SPMs regulate early LPS signaling, including activation of TLR4
Emmanuel Lorne et al.
Intensive care medicine, 36(11), 1826-1835 (2010-08-07)
Although the role of Toll-like receptors (TLRs) in bacterial infection and sepsis is well characterized, recent studies have also shown that TLR4 and TLR2 can play an important role in contributing to acute inflammatory processes and organ dysfunction in settings
Shneh Sethi et al.
Virulence, 2(4), 316-328 (2011-07-16)
Recent studies in murine models of Staphylococcus aureus (S. aureus) infection have investigated the association of Toll-like receptor (TLR)2, TLR4, myeloid differentiation factor 88 (MyD88) and Nod-like receptor (NOD)2 with the production of cytokines / chemokines and their involvement in
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