推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
mouse, human
技术
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CX3CL1(6376)
一般描述
Chemokine (C-X3-C motif) ligand 1 (CX3CL1) or fractalkine is a membrane protein and part of the CXC3 family. Its chemokine domain (CKD) anchors it to the cell membrane through its mucin-like stalk. The protein acts as a ligand for the G-protein coupled receptor CX3CR1. Fractalkine is expressed on epithelial, endothelial and smooth muscle cells and in neurons. The gene encoding it is localized on human chromosome 16q21.
免疫原
a peptide corresponding to 18 amino acids near the amino-terminus of human CX3CL1.
生化/生理作用
CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine is involved in various disorders such as atherosclerosis, multiple sclerosis, neuropathic pain and rheumatic disorders. It facilitates the proliferation and survival of primary human vascular smooth muscle cells in an epidermal growth factor receptor (EGR)–dependent manner. The protein plays an essential role in cell survival and promotes the survival of cells such as monocytes, T-cells and microglia. In humans, it may be involved in atherogenesis.
联系
The action of this antibody can be blocked using blocking peptide SBP2099.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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相关产品
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Fractalkine Promotes Human Monocyte Survival via a Reduction in Oxidative Stress
Gemma E White
Arteriosclerosis, Thrombosis, and Vascular Biology, 34(12), 2554?2562-2554?2562 (2014)
Gladys Morrison et al.
Stem cell research, 16(1), 140-148 (2016-01-17)
Differentiated cells retain the genetic information of the donor but the extent to which phenotypic differences between donors or batches of differentiated cells are explained by variation introduced during the differentiation process is not fully understood. In this study, we
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