推荐产品
生物来源
goat
质量水平
抗体形式
affinity purified immunoglobulin
抗体产品类型
primary antibodies
等级
Powered by Bethyl Laboratories, Inc.
种属反应性
human
浓度
1 mg/mL
技术
immunohistochemistry: 1:500-1:2,000
immunoprecipitation (IP): 2- 10 μg/mg
登记号
NP_005648.1
运输
wet ice
储存温度
2-8°C
靶向翻译后修饰
unmodified
基因信息
goat ... 53BP1(7158)
一般描述
p53 binding protein 1 (53BP1), also known as, tumor protein p53 binding protein 1, is homologous to the DNA damage checkpoint protein Rad9p of Saccharomyces cerevisiae. In the human chromosome, 53BP1 is localized on 15q15.3.
免疫原
The epitope recognized by PLA0303 maps to a region between residue 350 and 400 of human Tumor Protein p53 Binding Protein, 1 using the numbering given in entry NP_005648.1 (GeneID 7158).
生化/生理作用
p53 binding protein 1 (53BP1) is a transcriptional activator of tumour suppressor protein p53. 53BP1 senses the double strand DNA breaks induced by ionising radiations and chemicals and involved in the DNA repair pathway. 53BP1 is a downstream target of ataxia telangiectasia mutated (ATM) phosphorylation. 53BP1 binds to histone 3 lysine 79 methylated residues (H3K79) or dimethylated histone 4 lysine 20 (H4K20me2) via the tandem tudor domain, which enables its interaction with the double strand DNA breaks.
外形
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
其他说明
53BP1 (p53 Binding Protein 1) is an early participant in the cellular response to DNA double-strand breaks. 53BP1 functions in a redundant role in phosphorylation of the downstream checkpoint effector proteins Brca1 and Chk2 but was required for the formation of Brca1 foci in a hierarchical branched pathway for the recruitment of repair and signaling proteins to sites of DNA damage.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways
Rappold I, et al.
The Journal of Cell Biology, 153(3), 613-620 (2001)
p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks
Schultz LB, et al.
The Journal of Cell Biology, 151(7), 1381-1390 (2000)
53BP1 is a haploinsufficient tumor suppressor and protects cells from radiation response in glioma
Squatrito M, et al.
Cancer Research, canres-ca0045 (2012)
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
Huyen Y, et al.
Nature, 432(7015), 406-411 (2004)
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair
Botuyan MV, et al.
Cell, 127(7), 1361-1373 (2006)
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