所有图片(3)
IPOA4, SRP1, SRP1-gamma, SRP1gamma, SRP4, hSRP1, importin alpha 4, importin alpha Q2, importin alpha-3, importin subunit alpha-3, importin subunit alpha-4, importin-alpha-Q2, karyopherin alpha 3, karyopherin alpha 3 (importin alpha 4), karyopherin subunit alpha-3, qip2
生物来源
rabbit
质量水平
抗体形式
affinity purified immunoglobulin
抗体产品类型
primary antibodies
等级
Powered by Bethyl Laboratories, Inc.
种属反应性
human
技术
immunohistochemistry: 1:100- 1:500
immunoprecipitation (IP): 2-5 μg/mg
western blot: 1:2,000- 1:10,000
登记号
NP_002258.2
UniProt登记号
运输
wet ice
储存温度
2-8°C
基因信息
rabbit ... KPNA3(3839)
免疫原
The epitope recognized by PLA0200 maps to a region between residue 1 and 50 of human karyopherin alpha 3 using the numbering given in entry NP_002258.2 (GeneID 3839).
外形
Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide
其他说明
KPNA3 (karyopherin alpha 3), also known as importin alpha 4, is a member of the importin alpha family of proteins which includes KPNA1 (importin alpha 5), KPNA2 (importin alpha 1), KPNA3 (importin alpha 4), KPNA4 (importin alpha 3), KPNA5 (importin alpha 6), and KPNA6 (importin alpha 7). The importin alpha family of proteins plays a role in the import of proteins from the cytoplasm to the nucleus. The import of proteins from the cytoplasm to the nucleus involves docking the protein to receptors associated with the nuclear pore complex (NPC) followed by translocation through the nuclear pore. Importin alpha proteins bind the nuclear localization signal (NLS) of cargo proteins and function as adaptor proteins for the nuclear pore receptor KPNB1 (importin beta 1). KPNB1 is responsible for docking the importin-cargo complex to the cytoplasmic side of the NPC for its translocation through the NPC. KPNA3 (Importin alpha 4) and KPNA4 (importin alpha 3) have been reported to mediate the nuclear import of TNF-alpha induced nuclear import of NF-kappaB p50/p65 heterodimers. KPNA3 has also been reported to be responsible for the ligand-independent nuclear translocation of the vitamin D receptor.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
含少量动物源组分生物产品
常规特殊物品
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