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Merck
CN

PHG0004

SAFC

2-二(2-羟乙基)氨基-2-羟甲基-1,3-丙二醇

制药生产

别名:

2-二(2-羟乙基)氨基-2-羟甲基-1,3-丙二醇, 2-双(羟基甲基)-2,2′,2″-次氮基三乙醇, 双(2-羟乙基)氨基-三(羟甲基)甲烷

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About This Item

经验公式(希尔记法):
C8H19NO5
CAS号:
分子量:
209.24
Beilstein:
2205275
EC 号:
MDL编号:
UNSPSC代码:
12161705
NACRES:
NA.21

生物来源

synthetic

质量水平

形式

powder

技术

cell culture | mammalian: suitable

杂质

Endotoxin, microbial, and trace metals; tested

有效pH范围

5.8-7.2

pKa (25 °C)

6.5

溶解性

H2O: 0.1 M, clear, colorless

适用性

suitable for manufacturing use

异质活性

Cytotoxicity, DNase, NICKase, RNase, and Protease; tested

SMILES字符串

OCCN(CCO)C(CO)(CO)CO

InChI

1S/C8H19NO5/c10-3-1-9(2-4-11)8(5-12,6-13)7-14/h10-14H,1-7H2

InChI key

OWMVSZAMULFTJU-UHFFFAOYSA-N

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一般描述

我们用于生物制药加工的SAFC®系列优质原料经过严格的质量控制流程,配合记录文件和技术专长帮助我们的客户达到M-Clarity 计划规定的要求

M-Clarity 计划

缓冲液质量是生物制药工艺成功的关键,因为缓冲液几乎在每一个生产步骤中都是必不可少的。

我们广泛的缓冲材料产品线经过妥善管控,可根据您的需求量身定制。从低风险应用的非 GMP 等级,到高风险应用的 IPEC-PQG GMP标准,我们的产品可满足您的所有制造需求。

应用

Bis Tris 是一种常用的生物缓冲液,广泛用于生物系统,如诊断、电泳和基于蛋白质的生物处理。Bis Tris 的 pKa 为 6.36,这使得 Bis Tris 成为生物学制剂的良好选择。

Bis Tris 被广泛用于各种生物应用,包括蛋白分离缓冲液、细胞培养基、电泳分离和诊断试剂配方。

法律信息

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

替代产品

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Zahra Sabouri et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(25), E2567-E2575 (2014-05-14)
The best-understood mechanisms for achieving antibody self/non-self discrimination discard self-reactive antibodies before they can be tested for binding microbial antigens, potentially creating holes in the repertoire. Here we provide evidence for a complementary mechanism: retaining autoantibodies in the repertoire displayed
Alastair W Skeffington et al.
Plant physiology, 165(2), 866-879 (2014-05-02)
The first step on the pathway of starch degradation in Arabidopsis (Arabidopsis thaliana) leaves at night is the phosphorylation of starch polymers, catalyzed by glucan, water dikinase (GWD). It has been suggested that GWD is important for the control of
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Kidney international, 86(2), 433-444 (2013-12-20)
Micro RNAs (miRNAs) have been shown to circulate in biological fluids and are enclosed in vesicles such as exosomes; they are present in urine and represent a noninvasive methodology to detect biomarkers for diagnostic testing. The low abundance of RNA
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Disease models & mechanisms, 7(4), 471-481 (2014-02-08)
The purpose of our study was to compare two acquired muscle atrophies and the use of myostatin inhibition for their treatment. Myostatin naturally inhibits skeletal muscle growth by binding to ActRIIB, a receptor on the cell surface of myofibers. Because
X Chen et al.
Oncogene, 33(39), 4724-4734 (2013-10-22)
Uveal melanoma (UM) is a genetically and biologically distinct type of melanoma, and once metastatic there is no effective treatment currently available. Eighty percent of UMs harbor mutations in the Gαq family members GNAQ and GNA11. Understanding the effector pathways

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