product name
帕罗西汀 盐酸盐 半水合物, ≥98% (HPLC), powder
质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
white
创始人
GlaxoSmithKline
SMILES字符串
O.Cl[H].Fc1ccc(cc1)[C@@H]2CCNC[C@H]2COc3ccc4OCOc4c3
InChI
1S/C19H20FNO3.ClH.H2O/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;;/h1-6,9,14,17,21H,7-8,10-12H2;1H;1H2/t14-,17-;;/m0../s1
InChI key
QRQSGFFISBKLMZ-YHOFXEKLSA-N
基因信息
human ... SLC6A4(6532)
正在寻找类似产品? 访问 产品对比指南
应用
盐酸帕罗西汀半水合物已被用于：作为抗抑郁药，在体外用于研究其对胚胎大鼠海马神经干细胞（NSC）的影响 ；作为一种CYP 2D6抑制剂，研究其对人重组CYP 2D6体外生产酚类代谢物的影响；作为抗抑郁药，研究其对大鼠原代海马神经元垂体腺苷酸环化酶激活多肽（PACAP）、其受体和脑源性神经营养因子（BDNF）表达的影响
生化/生理作用
帕罗西汀是一种苯基哌啶衍生物。它具有穿过胎盘的能力。研究已发现帕罗西汀会增加先天性心脏畸形的风险。它可能在激素替代疗法中用于治疗更年期期间的血管舒缩症状。它已被发现可改善恐慌症、强迫症和社交恐惧症。
盐酸帕罗西汀半水化合物是选择性 5-羟色胺再摄取抑制剂 (SSRI) 中作用最强、选择性最强的一种；抗抑郁药
特点和优势
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
法律信息
经GlaxoSmithKline许可销售
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Paipai Guo et al.
Acta pharmaceutica Sinica. B, 14(3), 1222-1240 (2024-03-15)
Hyperplasia and migration of fibroblast-like synoviocytes (FLSs) are the key drivers in the pathogenesis of rheumatoid arthritis (RA) and joint destruction. Abundant Yes-associated protein (YAP), which is a powerful transcription co-activator for proliferative genes, was observed in the nucleus of
Koliane Ouk et al.
Neuropharmacology, 131, 337-350 (2017-12-25)
Circadian abnormalities seen in Huntington's disease (HD) patients are recapitulated in several HD transgenic mouse models. In mice, alongside the master clock located in the suprachiasmatic nucleus (SCN), two other oscillators may influence circadian behaviour. These are the food-entrainable oscillator
The metabolism of primaquine to its active metabolite is dependent on CYP 2D6
Pybus BS, et al.
Malaria Journal, 12(1), 212-212 (2013)
A review of paroxetine for the treatment of vasomotor symptoms
Slaton RM, et al.
Journal of Pharmacy Practice, 28(3), 266-274 (2015)
Joseph A Roscoe et al.
Breast cancer research and treatment, 89(3), 243-249 (2005-03-09)
Fatigue can significantly interfere with a cancer patient's ability to fulfill daily responsibilities and enjoy life. It commonly co-exists with depression in patients undergoing chemotherapy, suggesting that administration of an antidepressant that alleviates symptoms of depression could also reduce fatigue.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门