P9623
帕罗西汀 盐酸盐 半水合物
≥98% (HPLC), powder, serotonin reuptake inhibitor
别名:
盐酸帕罗西汀, （3S-反式）-3-\ [（1,3-苯并二氧戊环-5-氧基）甲基]-4-（4-氟苯基）哌啶 盐酸盐 半水合物
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选择尺寸
关于此项目
经验公式（希尔记法）:
C19H20FNO3 · HCl · .5 H2O
化学文摘社编号:
分子量:
374.83
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
帕罗西汀 盐酸盐 半水合物, ≥98% (HPLC), powder
SMILES string
O.Cl[H].Fc1ccc(cc1)[C@@H]2CCNC[C@H]2COc3ccc4OCOc4c3
InChI key
QRQSGFFISBKLMZ-YHOFXEKLSA-N
InChI
1S/C19H20FNO3.ClH.H2O/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;;/h1-6,9,14,17,21H,7-8,10-12H2;1H;1H2/t14-,17-;;/m0../s1
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white
originator
GlaxoSmithKline
Quality Level
Gene Information
human ... SLC6A4(6532)
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Application
盐酸帕罗西汀半水合物已被用于：作为抗抑郁药，在体外用于研究其对胚胎大鼠海马神经干细胞（NSC）的影响 ；作为一种CYP 2D6抑制剂，研究其对人重组CYP 2D6体外生产酚类代谢物的影响；作为抗抑郁药，研究其对大鼠原代海马神经元垂体腺苷酸环化酶激活多肽（PACAP）、其受体和脑源性神经营养因子（BDNF）表达的影响
Biochem/physiol Actions
帕罗西汀是一种苯基哌啶衍生物。它具有穿过胎盘的能力。研究已发现帕罗西汀会增加先天性心脏畸形的风险。它可能在激素替代疗法中用于治疗更年期期间的血管舒缩症状。它已被发现可改善恐慌症、强迫症和社交恐惧症。
盐酸帕罗西汀半水化合物是选择性 5-羟色胺再摄取抑制剂 (SSRI) 中作用最强、选择性最强的一种；抗抑郁药
选择性 5-羟色胺再摄取抑制剂；抗抑郁药
Features and Benefits
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
Legal Information
经GlaxoSmithKline许可销售
wgk
WGK 3
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Jonathan A Coleman et al.
eLife, 9 (2020-07-04)
Antidepressants target the serotonin transporter (SERT) by inhibiting serotonin reuptake. Structural and biochemical studies aiming to understand binding of small-molecules to conformationally dynamic transporters like SERT often require thermostabilizing mutations and antibodies to stabilize a specific conformation, leading to questions
Joseph A Roscoe et al.
Breast cancer research and treatment, 89(3), 243-249 (2005-03-09)
Fatigue can significantly interfere with a cancer patient's ability to fulfill daily responsibilities and enjoy life. It commonly co-exists with depression in patients undergoing chemotherapy, suggesting that administration of an antidepressant that alleviates symptoms of depression could also reduce fatigue.
Involvement of pituitary adenylate cyclase activating polypeptide (PACAP) and its receptors in the mechanism of antidepressant action
Reichenstein M, et al.
Journal of Molecular Neuroscience, 36(1-3), 330-330 (2008)
The risk of major cardiac malformations associated with paroxetine use during the first trimester of pregnancy: a systematic review and meta-analysis
Berard A, et al.
British Journal of Clinical Pharmacology, 81(4), 589-604 (2016)
The metabolism of primaquine to its active metabolite is dependent on CYP 2D6
Pybus BS, et al.
Malaria Journal, 12(1), 212-212 (2013)
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