P9256
Psychosine from bovine brain
lyophilized powder, ≥98% (HPLC)
别名:
1-β-D-Galactosylsphingosine
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关于此项目
经验公式（希尔记法）:
C24H47NO7
化学文摘社编号:
分子量:
461.63
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
InChI key
HHJTWTPUPVQKNA-PIIMIWFASA-N
SMILES string
CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O
InChI
1S/C24H47NO7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(27)18(25)17-31-24-23(30)22(29)21(28)20(16-26)32-24/h14-15,18-24,26-30H,2-13,16-17,25H2,1H3/b15-14+/t18-,19+,20+,21-,22-,23+,24+/m0/s1
form
lyophilized powder
storage temp.
−20°C
Quality Level
assay
≥98% (HPLC)
Application
Psychosine has been used as a lipid in lipid-protein overlay binding assay.
Biochem/physiol Actions
Psychosine is a neurotoxic lysosphingolipid and a glycolipid precursor for the synthesis of cerebrosides. It is synthesized from galactosylceramide, phrenosin. Elevated psychosine levels are implicated in Krabbe disease. It mediates demyelination and consequently oligodendrocytes degeneration. Psychosine is also correlated to neurological disease, Globoid cell leukodystrophy (GLD), where in galactosylceramidase (GALC) enzyme deficiency leads to its accumulation.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Hiroshi Yamamoto et al.
Archives of biochemistry and biophysics, 506(1), 83-91 (2010-11-18)
Sphingolipids act as signaling mediators that regulate a diverse range of cellular events. Although numerous sphingolipid functions have been studied, little is known about the effect of sphingolipids on monocyte differentiation into macrophages. Here, we report that two lysosphingolipids, sphingosylphosphorylcholine
Ludovico Cantuti Castelvetri et al.
Acta neuropathologica, 122(1), 35-48 (2011-03-05)
Loss-of-function of the lysosomal enzyme galactosyl-ceramidase causes the accumulation of the lipid raft-associated sphingolipid psychosine, the disruption of postnatal myelination, neurodegeneration and early death in most cases of infantile Krabbe disease. This work presents a first study towards understanding the
Lysosphingolipids and sphingolipidoses: Psychosine in Krabbe's disease
Spassieva S and Bieberich E
Journal of Neuroscience Research, 94(11), 974-981 (2016)
Benjamin Smith et al.
ASN neuro, 3(4), doi:10-doi:10 (2011-09-21)
Infantile Krabbe disease results in the accumulation of lipid-raft-associated galactosylsphingosine (psychosine), demyelination, neurodegeneration and premature death. Recently, axonopathy has been depicted as a contributing factor in the progression of neurodegeneration in the Twitcher mouse, a bona fide mouse model of
Wei-Lien Chuang et al.
Clinica chimica acta; international journal of clinical chemistry, 419, 73-76 (2013-02-20)
New York State has screened over 1.2 million newborns for Krabbe disease, and we identified 4 newborns with infantile Krabbe disease. In addition, 6 other newborns were identified with very low galactosylcerebrosidase (GALC) activity. Because these patients remain asymptomatic, we
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