P9156
纤溶酶原 来源于牛血浆
lyophilized powder, ≥2.0 units/mg protein
别名:
血纤维蛋白溶酶原
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352202
eCl@ss:
42030240
EC Number:
232-641-9
NACRES:
NA.61
MDL number:
产品名称
纤溶酶原 来源于牛血浆, lyophilized powder, ≥2.0 units/mg protein
biological source
bovine plasma
form
lyophilized powder
specific activity
≥2.0 units/mg protein
concentration
2-7% protein (biuret)
suitability
not suitable for streptokinase determination by clot formation procedure
application(s)
histology
storage temp.
2-8°C
Gene Information
cow ... PLG(280897)
human ... PLG(5340)
Biochem/physiol Actions
纤溶酶原是蛋白酶纤溶酶的无活性前体。纤溶酶原由组织型纤溶酶原激活剂 (tPA) 激活，tPA 主要激活纤溶酶的纤维蛋白溶解（血栓溶解）活性，或者由尿激酶型纤溶酶原激活剂 (uPA) 激活，uPA 与细胞外基质重塑和细胞迁移有关。纤溶酶可裂解纤维蛋白/纤维蛋白原和凝血因子 V/Va 以及 VIII/VIIIa。它可通过裂解非活性酶原激活基质金属蛋白酶。还与某些生长因子的激活有关，如血管內皮生長因子 (VEGF) 和转化生长因子 β (TGF-β)。
The activated form of plasminogen, plasmin, was shown to promote the migration of melanoma and lung tumor cells plated on the extracellular matrix protein laminin by altering protein kinase C signaling.
Other Notes
不含 ε-氨基己酸
当测定 5.0mL 体积中的高氯酸可溶性产物时，在 pH 7.5 和 37°C 下，一单位本品将使 α-酪蛋白在 20 分钟内产生 1.0 的 ΔA275。活性在尿激酶激活纤溶酶后测定。
Physical form
冻干粉，含 NaCl、EDTA、赖氨酸以及 Tris 缓冲盐
Preparation Note
溶液应储存在含 20mM 赖氨酸的中性 pH 缓冲液中。蛋白质应尽量浓缩。分成小份在 -20°C 下冻存，可稳定保存几周。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
低风险生物材料
此项目有
L Chikahisa et al.
Invasion & metastasis, 17(6), 323-333 (1997-01-01)
Using a pure chemotactic model, we investigated the effect of plasmin on tumor cell motility. In the presence of various extracellular matrix proteins, plasmin facilitated motility of human melanoma LOX and lung cancer Lu-99 cells. Laminin contributed most to the
Sudan Puri et al.
Stem cell research & therapy, 13(1), 384-384 (2022-07-31)
Hyaluronan (HA) has previously been identified as an integral component of the limbal stem cell niche in vivo. In this study, we investigated whether a similar HA matrix is also expressed in vitro providing a niche supporting limbal epithelial stem
Yueling Zhang et al.
FEBS letters, 587(9), 1304-1309 (2013-03-12)
Cluster 1 streptokinases (SK1) from Streptococcus pyogenes (GAS) show substantially higher human plasminogen (hPg) activation activities and tighter hPg binding affinities than cluster 2b streptokinases (SK2b) in solution. The extent to which the different domains of SK are responsible for
Barbara Ruszkowska et al.
Acta obstetricia et gynecologica Scandinavica, 92(7), 841-846 (2013-03-12)
To assess the concentration of adiponectin, soluble E-selectin, soluble thrombomodulin and tissue activator plasminogen antigen in postmenopausal women who received oral or transdermal hormone therapy. Case-control study. Polish university hospitals. Seventy-six healthy postmenopausal women. Forty-six women who received oral (n
Venous thrombosis in the nephrotic syndrome.
Joseph Loscalzo
The New England journal of medicine, 368(10), 956-958 (2013-03-08)
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