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Merck
CN

P8920

多聚-L-赖氨酸 溶液

0.1 % (w/v) in H2O

别名:

2-(4-氰基苯胺基)-4,6-二氯嘧啶, 4-[(4,6-二氯-2-嘧啶基)氨基]氰苯

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化学文摘社编号:
25988-63-0
UNSPSC Code:
41116121
eCl@ss:
32160406
NACRES:
NA.47
MDL number:
MFCD00165424

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产品名称

多聚-L-赖氨酸 溶液, 0.1 % (w/v) in H2O

SMILES string

N([C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)C(=O)[C@@H](N)CCCCN

InChI

1S/C18H38N6O4/c19-10-4-1-7-13(22)16(25)23-14(8-2-5-11-20)17(26)24-15(18(27)28)9-3-6-12-21/h13-15H,1-12,19-22H2,(H,23,25)(H,24,26)(H,27,28)/t13-,14-,15-/m0/s1

InChI key

WBSCNDJQPKSPII-KKUMJFAQSA-N

biological source

synthetic

shelf life

Expiry date on the label.

mol wt

150,000-300,000

concentration

0.1 % (w/v) in H2O

color

colorless

application(s)

hematology
histology

storage temp.

room temp

Quality Level

200

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Application

聚-L-赖氨酸溶液已用于将内皮细胞横截面附着到UV交联的PET膜框架玻片上。聚-L-赖氨酸涂覆的玻片用于放置用于免疫组化检测的组织切片。
聚-L-赖氨酸聚合物可用于促进细胞对固体底物的粘附、与甲氨蝶呤结合以增加药物转运、胰岛微囊化、细胞微囊化技术、微阵列玻片涂层和染色体制剂。 较低分子量的聚-L-赖氨酸（30000-70000）在溶液中粘度较低，但分子量较高的聚赖氨酸在每个分子中提供更多的附着位点。

Biochem/physiol Actions

聚-L-赖氨酸是一种非特异性的细胞附着因子，通过增强细胞膜负离子与培养基表面的静电相互作用，促进细胞对固体基质的粘附。 当其吸附到细胞培养表面时，聚-L-赖氨酸的作用是增加可用于细胞结合的带正电荷位点的数量。 对于可降解聚-L-赖氨酸的细胞，应采用聚-D-赖氨酸作为附着因子。

Other Notes

聚-L-赖氨酸是一种带正电荷的氨基酸聚合物，每个赖氨酸残基约有一个HBr。 氢溴酸盐可使聚-L-赖氨酸以可溶于水的结晶形式存在。 在β结构中可能会发现少量的产物，因为HBr干扰氨基与羧基或含N或O部分之间的氢键。

Preparation Note

该产品以0.10％（w/v）水溶液形式提供的。用该溶液进行涂覆的玻片应当随后进行一步5分钟的孵育并在室温对其进行干燥。 涂覆的玻片在免收灰尘的保护下可稳定一年。

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

存储类别

12 - Non Combustible Liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000405469
0000405469
0000405466
0000405466
0000353387

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. Is Product P8920, Poly-L-lysine solution, recommended for cell culture use?

    No, the product contain 0.01% thimerosal as a preservative. For cell culture use, product P4832 is recommended.  This solution has the same molecular weight as P8920 but contains no preservative.  P4832 is sterile filtered and is considered suitable for cell culture use.

  4. What are the recommended uses for Product P8920, Poly-L-lysine solution?

    P8920 was developed for use in coating slides intended for use in either histology or immunohistochemistry.  Poly-L-lysine is preferred for uses such as silver staining procedures that require an alkaline pH.  Silane coated slides may be more effective is a low pH is required.

  5. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  6. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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Product Information Sheet - P8920

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