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Merck
CN

P8688

(S)-(-)-普奈洛尔 盐酸盐

≥98% (TLC), β1- and β2-aadrenergic receptor blocker, powder

别名:

(S)-1-异丙基氨基-3-(1-萘氧基)-2-丙醇 盐酸盐

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关于此项目

线性分子式:
C10H7OCH2CH(OH)CH2NHCH(CH3)2·HCl
化学文摘社编号:
4199-10-4
分子量:
295.80
NACRES:
NA.77
PubChem Substance ID:
24278657
UNSPSC Code:
12352200
EC Number:
224-096-0
MDL number:
MFCD00064547
Beilstein/REAXYS Number:
3574966

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产品名称

(S)-(-)-普奈洛尔 盐酸盐, ≥98% (TLC), powder

InChI key

ZMRUPTIKESYGQW-UQKRIMTDSA-N

InChI

1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H/t14-;/m0./s1

SMILES string

Cl[H].CC(C)NC[C@H](O)COc1cccc2ccccc12

assay

≥98% (TLC)

form

powder

optical activity

[α]25/D −25.5°, c = 1.0 in ethanol(lit.)

mp

193-195 °C (lit.)

solubility

ethanol: 10 mg/mL
DMSO: <14.5 mg/mL
H2O: 50 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL

originator

AstraZeneca

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... ADRB1(153), ADRB2(154), ADRB3(155), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355)

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相关类别

Application

(S)-(−)-Propranolol hydrochloride has been used:
  • as a non-selective β-blocker propranolol to inhibit the actions of epinephrine in mice
  • as a β1- and β2-aadrenergic receptor blocker in rat
  • as a medium supplement to investigate its effect on adipogenesis in hemangioma-derived stem cells (HemSC)

Biochem/physiol Actions

(S)-(−)-Propranolol hydrochloride is biologically active enantiomer. It acts as β1 receptor antagonist in thalamocortical neurons. (S)-(−)-Propranolol hydrochloride elicits its inhibitory function on the β1 adrenoceptor in trigeminovascular pain pathway and serves as a preventive medicine in migraine.
Active β-adrenoceptor blocking enantiomer, as measured by inhibition of isoprenaline-induced tachycardia; Propranolol is also non-specific 5-HT1A, 5-HT1B and 5-HT1C serotonin receptor antagonist. The stereoselective association of mianserin and propranolol with the 5HT1A, 5HT1B and 5HT1C sites may prove useful in the characterization of these sites

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

With heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

监管及禁止进口产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000467769
0000467769
0000415097
0000415097
0000399276

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Rizaldy C Zapata et al.
The Journal of nutritional biochemistry, 65, 115-127 (2019-01-28)
Moderate dietary protein restriction promotes hyperphagia and thermogenesis; however, little is known of whether these responses are due to restriction of the essential amino acids tryptophan and histidine. Here, we determined whether restriction of tryptophan and histidine alone recapitulate the
Matthew J Shepard et al.
Journal of neurosurgery, 1-9 (2018-12-01)
OBJECTIVEVon Hippel-Lindau disease (VHL) is a tumor predisposition syndrome characterized by CNS hemangioblastomas (HBs) and clear cell renal cell carcinomas (RCCs) due to hypoxia-inducible factor activation (pseudohypoxia). Because of the lack of effective medical therapies for VHL, HBs and RCCs
Yee Yin Ho et al.
Food & function, 8(6), 2110-2114 (2017-05-18)
We found that intraduodenal administration of l-ornithine (l-Orn) stimulates growth hormone (GH) secretion in Wistar rats, and then investigated its mechanism. GH-releasing activity after intraduodenal administration of l-Orn was blocked by [d-Lys
Dietary Tryptophan Restriction Dose-Dependently Modulates Energy Balance, Gut Hormones, and Microbiota in Obesity-Prone Rats
Zapata RC, et al.
Obesity (Silver Spring, Md.), 26(4), 730-739 (2018)
Insulin-like growth factor 2 promotes the adipogenesis of hemangioma-derived stem cells
Zhang K, et al.
Experimental and Therapeutic Medicine, 17(3), 1663-1669 (2019)
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Product Information Sheet - P8688

Product Information Sheet

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