P8477
Picotamide
别名:
4-Methoxy-N,N′-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide
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关于此项目
经验公式（希尔记法）:
C21H20N4O3
化学文摘社编号:
分子量:
376.41
NACRES:
NA.83
PubChem Substance ID:
UNSPSC Code:
12352204
EC Number:
251-245-7
MDL number:
InChI
1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27)
InChI key
KYWCWBXGRWWINE-UHFFFAOYSA-N
SMILES string
COc1ccc(cc1C(=O)NCc2cccnc2)C(=O)NCc3cccnc3
assay
≥98%
form
powder
solubility
ethanol: 50 mg/mL, clear, colorless to light yellow
Quality Level
Gene Information
human ... TBXA2R(6915)
Biochem/physiol Actions
Eicosenoid receptor antagonist; a thromboxane A2 antagonist; antiplatelet agent.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
P A Modesti et al.
European journal of pharmacology, 169(1), 85-93 (1989-10-04)
On the basis of indirect pharmacological evidence, picotamide, a methoxy derivative of 4-hydroxy-isophthalic acid (N,N'bis(3-picolyl)-4-methoxy-isophthalamide) has been postulated to inhibit platelet aggregation by competitively interfering with the thromboxane A2 (TxA2) platelet receptor. In the present study the interaction between picotamide
A Giustina et al.
Diabetes, 47(3), 423-430 (1998-03-31)
Picotamide both inhibits thromboxane synthetase and acts as a thromboxane antagonist at the receptor level. We investigated the long-term effect of picotamide on urinary albumin excretion (UAE) at rest and induced by exercise in 30 type 2 diabetic patients who
S Basili et al.
Haematologica, 83(8), 701-707 (1998-10-30)
Prospective studies have shown that high plasma levels of fibrinogen are independently associated with the risk of cardiovascular complications. In patients suffering from peripheral vascular disease (PVD) fibrinogen has been shown to be an independent predictor of cardiovascular disease but
Sergio Castellani et al.
Journal of the American College of Cardiology, 42(1), 133-139 (2003-07-10)
The aim of this study was to evaluate whether thromboxane inhibition can favorably affect renal perfusion and clinical conditions in patients affected by severe heart failure. The renal formation of the vasoconstrictor thromboxane A(2) (TxA(2)) is increased during cardiac failure.
Gian Gastone Neri Serneri et al.
European heart journal, 25(20), 1845-1852 (2004-10-12)
Patients with diabetes are at excessive risk of mortality and cardiovascular morbidity. Previous studies suggest that aspirin may be less effective in diabetic patients. In this multi-centre, randomized, double blind trial picotamide, a dual inhibitor of thromboxane A2 synthase and
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