推荐产品
生物来源
Porcine
方案
≥95%
表单
powder
溶解性
DMF: methanol (1:1): soluble-10 mg/mL, dark red-brown
荧光
λex 402 nm; λem 625 nm (bound to HRP)
λex 409 nm; λem 633 nm
储存温度
2-8°C
SMILES字符串
Cc1c(CCC(O)=O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5C=C)c(C)c4C=C)c(C)c3CCC(O)=O
InChI
1S/C34H34N4O4/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25/h7-8,13-16,35,38H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42)/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-
InChI key
KSFOVUSSGSKXFI-UJJXFSCMSA-N
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一般描述
原卟啉IX使血红素呈红色，是血液中的主要卟啉。在存在原卟啉原IX氧化酶的条件下，其由原卟啉原IX合成。
原卟啉IX属于卟啉家族，是一类四吡咯。它是氯高铁血红素的无铁形式，并且天然具有两亲性质。它是生物合成途径中血红素的前体。
应用
原卟啉IX已被用于：
- 作为原卟啉测定的标准品
- 荧光光谱分析中
- 处理细胞培养中的细胞以研究血红素介导的铁转运蛋白1的转录
可激活可溶性鸟苷酸环化酶。
生化/生理作用
原卟啉IX可以穿透人体红细胞并帮助它们释放氧气。它可与肌红蛋白和血红蛋白形成复合物。它可用作癌症光动力疗法的光敏剂。
原卟啉IX在肿瘤细胞之中存在代谢异常，因此含量水平相对于正常细胞有所升高。
相关产品
产品编号
说明
价格
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter.
Marro S
Haematologica, 95(8), 1261-1268 (2010)
Cobalt protoporphyrin IX increases endogenous G-CSF and mobilizes HSC and granulocytes to the blood.
Agata Szade et al.
EMBO molecular medicine, 11(12), e09571-e09571 (2019-11-12)
Granulocyte colony-stimulating factor (G-CSF) is used in clinical practice to mobilize cells from the bone marrow to the blood; however, it is not always effective. We show that cobalt protoporphyrin IX (CoPP) increases plasma concentrations of G-CSF, IL-6, and MCP-1
Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 5-aminolevulinic acid correlates with localized protoporphyrin IX fluorescence.
Divaris DX
The American Journal of Pathology, 136(4), 891-897 (1990)
Ki Mo Kim et al.
Environmental toxicology and pharmacology, 48, 85-93 (2016-10-23)
Coniferaldehyde (CA) exerts anti-inflammatory properties by inducing heme oxygenase-1 (HO-1). To define the regulation mechanism by which CA induces a cytoprotective function and HO-1 expression, the up-stream regulations involved in the activation of nuclear transcription factor-erythroid 2-related factor (Nrf)-2/HO-1 pathway
J Flemmig et al.
Free radical research, 50(12), 1386-1395 (2016-10-26)
Excessive release of hemoglobin from red blood cells markedly disturbs the health status of patients due to cytotoxic effects of free hemoglobin and heme. The latter component is able to initiate novel hemolytic events in unperturbed red blood cells. We
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