产品名称
抗P2X7 嘌呤能受体 兔抗, affinity isolated antibody, lyophilized powder
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human, mouse, rat
technique(s)
immunohistochemistry: suitable
western blot: 1:200-1:1,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... P2RX7(5027)
mouse ... P2rx7(18439)
rat ... P2rx7(29665)
Application
兔抗P2X7嘌呤能受体抗体可用于
- 免疫沉淀
- 免疫荧光和共聚焦显微镜
- 蛋白质印迹法
Biochem/physiol Actions
嘌呤能受体P2X7在免疫过程中起作用。它在病理条件下的氧化应激中起作用。 该通道允许Na+、Ca2+和K+通过。在某些病理条件下，通道长时间激活会导致大分子通过，最终导致细胞死亡。P2X7可参与白介素1β（IL-1）的释放，间接引发炎症级联反应。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
嘌呤能受体P2X7是ATP门控阳离子通道。它在视网膜色素上皮和神经视网膜中表达。编码该蛋白的基因位于人类12号染色体上。
Immunogen
肽（C）KIRKEFPKTQGQYSGFKYPY，对应于大鼠P2X7受体（登录号Q64663）的氨基酸残基576-595。细胞内，C端。
Other Notes
想要使用各种技术和制备方法都能获得最佳结果，我们推荐通过滴定确定最佳工作稀释度。
Physical form
从含有1％牛血清白蛋白和0.05％叠氮化钠的磷酸盐缓冲液（pH 7.4）中冻干。
Preparation Note
复溶前，–20°C储存。复溶后，抗体储备溶液可在2–8°C储存两周。若需延长储存时间，可将溶液按使用量分装后在-20°C下冻存。不建议反复冻融。不建议在无霜冰箱中储存。使用前离心所有抗体制剂（10000 x g，5 min）。若工作稀释样品在12小时内未使用完，则应丢弃。
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存储类别
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Anna Pegoraro et al.
Cell death & disease, 11(10), 876-876 (2020-10-20)
Acute myeloid leukemia (AML) is a common adult leukemia often arising from a preexistent myelodysplastic syndrome (MDS). High mortality rates of AML are caused by relapse and chemoresistance; therefore, we analyzed the role of P2X7 receptor (P2X7R) splice variants A
The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein
Alessia Franceschini
Faseb Journal (2015)
Li Jiang et al.
Journal of neuroinflammation, 18(1), 5-5 (2021-01-07)
Central sensitization is an important pathophysiological mechanism of chronic migraine (CM). According to our previous studies, microglial activation and subsequent inflammation in the trigeminal nucleus caudalis (TNC) contribute to the central sensitization. The P2X7 receptor (P2X7R) is a purinergic receptor
Lack of the P2X7 receptor protects against AMD-like defects and microparticle accumulation in a chronic oxidative stress-induced mouse model of AMD.
Carver KA
Biochemical and Biophysical Research Communications, 482(1), 81-86 (2017)
Anna Pegoraro et al.
Cell death & disease, 12(12), 1088-1088 (2021-11-19)
Tumor growth and metastatic spreading are heavily affected by the P2X7 receptor as well as microvesicles and exosomes release into the tumor microenvironment. P2X7 receptor stimulation is known to trigger vesicular release from immune and central nervous system cells. However
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