P8087
Monoclonal Anti-Plakoglobin (Catenin γ) antibody produced in mouse
clone 15F11, ascites fluid, buffered aqueous solution
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关于此项目
Conjugate:
unconjugated
Clone:
15F11, monoclonal
Application:
ARR, ICC, IF, IHC (f), IP, WB
Citations:
16
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
15F11, monoclonal
form
buffered aqueous solution
mol wt
antigen 85 kDa
contains
15 mM sodium azide
species reactivity
bovine, canine, human
technique(s)
immunocytochemistry: suitable using cultured cells, immunohistochemistry (frozen sections): suitable, immunoprecipitation (IP): suitable, indirect immunofluorescence: 1:1,000 using cultured MDBK cells, microarray: suitable, western blot: 1:2,000 using cultured MDBK cells
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... JUP(3728)
General description
Plakoglobin is a desmosomal protein that regulates developmental signalling in vertebrates. Tyrosine phosphorylation of plakoglobin has been linked to adenocarcinomas . Plakoglobin may function as a tumor suppressor in ovarian and breast cancers .
Immunogen
recombinant chicken plakoglobin.
Application
Monoclonal anti-plakoglobin (catenin γ) antibody is suitable for use in immunocytochemistry (using MDCK cells), immunoprecipitation, and in immunoblotting . The antibody may also be used for immunohistochemistry (frozen sections), microarray, western blot (1:500, using cultured MDBK cells) and indirect immunofluorescence (1:1000, using cultured MDBK cells).
Biochem/physiol Actions
The antibody recognizes the plakoglobin (catenin-γ) molecule (85 kDa and possibly a slightly lower band) by immunoblotting. It does not cross-react with β-catenin. The antibody reacts with plakoglobin in bovines, humans and dogs, but does not react with β catenin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
动植物来源生物产品
此项目有
S Shibamoto et al.
Cell adhesion and communication, 1(4), 295-305 (1994-01-01)
The effect of hepatocyte growth factor/scatter factor (HGF/SF) and epidermal growth factor (EGF) on cadherin-mediated adhesion of human carcinoma cells was studied. HGF/SF induced scattering of colonic adenocarcinoma HT29 and gastric adenocarcinomas MKN7 and MKN74 cells. Likewise, EGF induced scattering
Rene L Begay et al.
JACC. Clinical electrophysiology, 4(4), 504-514 (2018-08-02)
The purpose of this study was to assess the phenotype of Filamin C (FLNC) truncating variants in dilated cardiomyopathy (DCM) and understand the mechanism leading to an arrhythmogenic phenotype. Mutations in FLNC are known to lead to skeletal myopathies, which
Carlos Bueno-Beti et al.
Progress in pediatric cardiology, 64, None-None (2022-03-19)
The diagnosis of arrhythmogenic cardiomyopathy (ACM) is challenging especially in children at risk of adverse events. Analysis of cardiac myocyte junctional protein distribution may have diagnostic and prognostic implications, but its utility is limited by the need for a myocardial
Willem B van Ham et al.
Journal of cardiovascular development and disease, 10(8) (2023-08-25)
The development of the normal human heart, ranging from gestational age to the mature adult heart, relies on a very delicate and timely orchestrated order of processes. One of the most striking alterations in time is the gradual extinction of
H Aberle et al.
Proceedings of the National Academy of Sciences of the United States of America, 92(14), 6384-6388 (1995-07-03)
The gene encoding human plakoglobin was mapped to chromosome 17q12-q22. An intragenic restriction fragment length polymorphism was used to localize the plakoglobin gene distal to locus KRT10 and proximal to the marker D17S858. The plakoglobin gene colocalizes with the polymorphic
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