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Merck
CN
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文件

P8014

Sigma-Aldrich

4α-佛波醇 12,13-二癸酸酯

solid

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别名:
4α-佛波醇 12-13-二癸酸酯, 4αPDD
经验公式（希尔记法）:
C40H64O8
CAS号:
27536-56-7
分子量:
672.93
Beilstein:
2514324
MDL编号:
MFCD00036737
UNSPSC代码:
12352211
PubChem化学物质编号:
24898900
NACRES:
NA.77

形式

solid

质量水平

100

颜色

white

溶解性

DMSO: soluble
ethanol: soluble
methanol: soluble

储存温度

−20°C

SMILES字符串

CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@]3(O)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(=O)CCCCCCCCC

InChI

1S/C40H64O8/c1-7-9-11-13-15-17-19-21-32(42)47-36-28(4)39(46)30(24-29(26-41)25-38(45)31(39)23-27(3)35(38)44)34-37(5,6)40(34,36)48-33(43)22-20-18-16-14-12-10-8-2/h23-24,28,30-31,34,36,41,45-46H,7-22,25-26H2,1-6H3/t28-,30+,31-,34-,36-,38+,39-,40-/m1/s1

InChI key

DGOSGFYDFDYMCW-OEFRVDPMSA-N

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相关类别

应用

4α-佛波醇12,13-二癸酸酯作为瞬时受体电位香草醛4(TRPV4)激动剂的应用实例：
  • 研究其对Madin-Darby犬肾(MDCK)细胞的影响
  • 研究其对小鼠输卵管细胞Ca2+内流的影响
  • 研究其对小鼠足趾肿胀的影响

生化/生理作用

4α-佛波醇12,13-二癸酸酯是一种瞬时受体电位香草醛4(TRPV4)激动剂，可促进胞外钙离子内流进入细胞。

注意

光敏性

重悬

不能使用水性介质制备储液；溶解于与水混溶的有机溶剂中，然后在水性介质中稀释至工作浓度。

警示用语：

Danger

危险分类

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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W M Baird et al.
Cancer research, 31(8), 1074-1079 (1971-08-01)
T A Rose-Hellekant et al.
Molecular reproduction and development, 44(2), 250-255 (1996-06-01)
The purpose of this investigation was to determine if precocious oocyte maturation could be induced by modulating ovarian cAMP-dependent protein kinase (PKA) or protein kinase C (PKC) signal transduction pathways in the intact hamster. The following inhibitors and stimulators were
Lei Chen et al.
Neuroscience letters, 452(1), 79-83 (2009-05-16)
The present study explored the effect of anisotonicity on action potential (AP) in cultured trigeminal ganglion (TG) neurons. We demonstrate that the number of evoked APs was increased by both hypo- and hypertonic treatment. Transient Receptor Potential Vanilloid 4 receptor
Y Fukushima et al.
The Biochemical journal, 320 ( Pt 1), 27-32 (1996-11-15)
The histamine H2 receptor is a member of the family of G-protein-coupled receptors and is linked to the activation of adenylate cyclase phospholipase C (PLC). In this study we examined the effects of protein kinase C (PKC) activation in Chinese
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Neuroscience letters, 678, 76-82 (2018-05-08)
Pain management remains a major concern regarding the treatment of postoperative patients. Transient receptor potential (TRP) channels are considered to be new therapeutic targets for pain control. We investigated whether the genes Trpv1 and Trpv4 are involved in hind paw
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