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溶解性
1 M HCl: soluble 50 mg/mL
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
作用机制
cell wall synthesis | interferes
储存温度
2-8°C
SMILES字符串
[Ca++].CC1OC1P([O-])([O-])=O
InChI
1S/C3H7O4P.Ca/c1-2-3(7-2)8(4,5)6;/h2-3H,1H3,(H2,4,5,6);/q;+2/p-2
InChI key
YMZJBJPWTXJQMR-UHFFFAOYSA-L
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应用
Phosphomycin, also known as Fosfomycin, is an antibiotic produced by Streptomyces fradiae. It is used to treat uncomplicated urinary tract infections and to reduce nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. It is used to study resistance proteins in Bacillus subtilis and Mycobacterium tuberculosis. It is a potential treatment for bronchiectasis.
生化/生理作用
Fosfomycin is a phosphoenolpyruvate analog. It irreversibly inhibits enolpyruvate transferase (MurA). Therefore, the producion of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall is inhibited.
Phosphomycin calcium salt blocks the formation or N-acetylmuramic acid by inhibiting UDP-Nacetylglucosamine 3-enolpyruvate transferase (MurA).
其他说明
Keep container tightly closed in a dry and well-ventilated place.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
David L MacLeod et al.
The Journal of antimicrobial chemotherapy, 64(4), 829-836 (2009-08-15)
To compare the in vitro and in vivo activities of a 4:1 (w/w) fosfomycin/tobramycin combination (FTI) with those of fosfomycin and tobramycin alone against cystic fibrosis (CF) and non-CF bronchiectasis pathogens. Clinical isolates of CF Pseudomonas aeruginosa, Staphylococcus aureus, Haemophilus
M Cao et al.
Journal of bacteriology, 183(7), 2380-2383 (2001-03-13)
We demonstrate that the Bacillus subtilis fosB(yndN) gene encodes a fosfomycin resistance protein. Expression of fosB requires sigma(W), and both fosB and sigW mutants are fosfomycin sensitive. FosB is a metallothiol transferase related to the FosA class of Mn(2+)-dependent glutathione
K A De Smet et al.
Microbiology (Reading, England), 145 ( Pt 11), 3177-3184 (1999-12-10)
Mycobacterium tuberculosis has innate resistance to a range of broad-spectrum antimicrobial agents. This may in part reflect the relative impermeability of the mycobacterial cell wall, but additional specific mechanisms may also be important. In the case of fosfomycin, it has
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