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P7340

(±)-苏-1-苯基-2-癸酰氨基-3-吗啉-1-丙醇盐酸盐

Name: (±)-<I>苏</I>-1-苯基-2-癸酰氨基-3-吗啉-1-丙醇 盐酸盐
Brand: SIGMA

别名:

(±)-苏-PDMP 盐酸盐, PDMP 盐酸盐

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About This Item

经验公式（希尔记法）:

C₂₃H₃₈N₂O₃·HCl

CAS号:

80938-69-8

分子量:

427.02

MDL编号:

MFCD00236490

UNSPSC代码:

12352200

PubChem化学物质编号:

24278649

NACRES:

NA.77

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DL-苏式-1-苯基-2-棕榈酰氨基-3-吗啉-1-丙醇

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3,3′,5-三碘-L-甲状腺氨酸钠盐

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Glucosylceramide Synthase Inhibitor, Genz-123346

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亚硒酸钠

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β-雌二醇

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T2877

3,3′,5-三碘代-L-甲状腺原氨酸

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P8783

黄体酮

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P0503

O-磷酸乙醇胺

生物来源

synthetic (organic)

质量水平

100

方案

≥98% (TLC)

表单

powder

溶解性

water: 50 mg/mL, clear, colorless

储存温度

−20°C

SMILES字符串

Cl.CCCCCCCCCC(=O)N[C@H](CN1CCOCC1)[C@H](O)c2ccccc2

InChI

1S/C23H38N2O3.ClH/c1-2-3-4-5-6-7-11-14-22(26)24-21(19-25-15-17-28-18-16-25)23(27)20-12-9-8-10-13-20;/h8-10,12-13,21,23,27H,2-7,11,14-19H2,1H3,(H,24,26);1H/t21-,23-;/m1./s1

InChI key

HVJHJOYQTSEKPK-BLDCTAJRSA-N

生化/生理作用

葡萄糖神经酰胺合成酶抑制剂；阻止由神经酰胺形成葡萄糖基神经酰胺。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Inhibition of glycosphingolipid synthesis by threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) and the modulation of IL-1beta-stimulated expression of inducible nitric oxide synthase in rat aortic smooth muscle cells.

A A Weber et al.

British journal of pharmacology, 123(5), 906-910 (1998-04-16)

1. The composition of glycosphingolipids is altered in atherosclerotic tissue. In order to study the possible modulation of interleukin-1beta (IL-1beta)-induced expression of inducible nitric oxide synthase (iNOS) by endogenously synthesized glycosphingolipids, we investigated rat aortic vascular smooth muscle cells (VSMC)

Effects of D-threo-PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells.

J Inokuchi et al.

Journal of cellular physiology, 141(3), 573-583 (1989-12-01)

Incubating B16 melanoma cells with an inhibitor of glucosylceramide (GlcCer) synthetase, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-threo-PDMP), led to a considerable decrease in the levels of GlcCer and lactosylceramide (LacCer). The content of ganglioside GM3 was little affected, but the ability to bind a

Endogenous β-glucocerebrosidase activity in Abca12⁻/⁻epidermis elevates ceramide levels after topical lipid application but does not restore barrier function.

Jorge F Haller et al.

Journal of lipid research, 55(3), 493-503 (2013-12-03)

ABCA12 mutations disrupt the skin barrier and cause harlequin ichthyosis. We previously showed Abca12(-/-) skin has increased glucosylceramide (GlcCer) and correspondingly lower amounts of ceramide (Cer). To examine why loss of ABCA12 leads to accumulation of GlcCer, de novo sphingolipid

Radin, et al.

Journal of Lipid Research, 26, 183-213 (1993)

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