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Merck
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文件

P6500

Sigma-Aldrich

戊四唑

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别名:
1,5-五亚甲基-1H-四唑, 6,7,8,9-四氢-5H-四唑并氮杂卓, 戊四氮, 戊撑四唑
经验公式（希尔记法）:
C6H10N4
CAS号:
54-95-5
分子量:
138.17
EC 号:
200-219-3
MDL编号:
MFCD00005939
UNSPSC代码:
12352200
PubChem化学物质编号:
24278643
NACRES:
NA.77

形式

powder

质量水平

100

bp

194 °C/12 mmHg (lit.)

mp

59-61 °C (lit.)

储存温度

−20°C

SMILES字符串

C1CCc2nnnn2CC1

InChI

1S/C6H10N4/c1-2-4-6-7-8-9-10(6)5-3-1/h1-5H2

InChI key

CWRVKFFCRWGWCS-UHFFFAOYSA-N

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一般描述

戊四唑（PTZ）为四唑衍生物，是γ氨基丁酸（GABAA）及其受体复合物的抑制剂。 PTZ是用于诱发惊厥的惊厥剂。可穿透血脑屏障。

应用

戊四唑用于诱发斑马鱼幼虫 、小鼠 和雄性Wistar大鼠发生惊厥。

生化/生理作用

戊四唑是非特异性中枢神经系统（CNS）兴奋剂和惊厥剂。PTZ诱发氧化应激，增加皮质内丙二醛含量并影响海马体功能，导致发生惊厥。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

分析证书(COA)

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. How do I solubilize Product P6500, Pentylenetetrazole?

    We test the solubility of this compound at a concentration of 50 mg/mL in water.

  6. What is the solution stability for Product P6500, Pentylenetetrazole?

    We do not have any solution stability information for this product.  It is always best to make a fresh solution. If this is not possible, you can try storing solution in single use aliquots at -20°C.

  7. Can Product P6500, Pentylenetetrazole, be used to induce convulsions?

    Pentylenetetrazole induced convulsions have been reported by De Sarro G. et al., in Eur. J. Pharmacol., 368(2-3),149-159 (1999).

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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PloS one, 8(1), e54166-e54166 (2013-01-24)
Zebrafish have recently emerged as an attractive in vivo model for epilepsy. Seven-day-old zebrafish larvae exposed to the GABA(A) antagonist pentylenetetrazol (PTZ) exhibit increased locomotor activity, seizure-like behavior, and epileptiform electrographic activity. A previous study showed that 12 out of
Rufi Tambe et al.
Pharmaceutical biology, 55(1), 264-268 (2016-12-09)
Eclipta alba (Linn) Hassk. (Asteraceae) has been reported to be a nerve tonic and has been used to treat epilepsy in folk medicine. The present study isolates and characterizes luteolin from E. alba and evaluates its antiepileptic potential in chemically
Ervand G Paronikyan et al.
MedChemComm, 10(8), 1399-1411 (2019-09-20)
8-Hydrazino derivatives of pyrano[3,4-c]pyridines and derivatives of the new heterocyclic system 3-thioxopyrano[3,4-c][1,2,4]triazolo[4,3-a]pyridines on the basis of methanesulfonates of pyrano[3,4-c]pyridinium were synthesized by optimization of a previously used method. Derivatives of alkylsulfonyl pyrano[3,4-c][1,2,4]triazolo[4,3-a]pyridines were also synthesized. All compounds were evaluated for
Mehwish Anwer et al.
Scientific reports, 9(1), 11819-11819 (2019-08-16)
Traumatic brain injury (TBI) causes neuroendocrine dysregulation in up to 40% of humans, which is related to impaired function of the hypothalamo-hypophyseal axis and contributes to TBI-related co-morbidities. Our objective was to investigate whether hypophyseal atrophy can be recapitulated in
Perineuronal net degradation in epilepsy
Rankin-Gee EK, et al.
Epilepsia, 56(7), 1124-1133 (2015)
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