生物来源
synthetic
质量水平
检测方案
≥96% (HPLC)
形式
powder
颜色
white to off-white
溶解性
H2O: 1 mg/mL (Hydrolyzes to 6-ketoprostaglandin F1α in aqueous solution.)
ethanol: 50 mg/mL
官能团
carboxylic acid
hydroxyl
运输
ambient
储存温度
−20°C
SMILES字符串
CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@@](O/2)([H])[C@]1([H])CC2=C\CCCC(O)=O.[Na]
InChI
1S/C20H32O5.Na/c1-2-3-4-8-15(21)10-11-16-17(22)12-18-20(16)14(13-25-18)7-5-6-9-19(23)24;/h7,10-11,15-18,20-22H,2-6,8-9,12-13H2,1H3,(H,23,24);/q;+1/p-1/b11-10+,14-7-;/t15-,16-,17+,18-,20+;/m0./s1
InChI key
OURCVRVJQMLUNA-QFDVFERUSA-M
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应用
前列腺素I2钠盐已用于以下情形：
- 制备储备溶液，用于血小板洗涤程序
- 在富血小板血浆中用作补充剂，用于血小板制剂
- 防止血小板激活
生化/生理作用
前列环素是血管内皮细胞中环氧合酶途径的一种短期产物。通过拮抗血栓烷A2和刺激血小板腺苷酸环化酶，用作血小板聚集的有效抑制剂。一氧化氮也在血管内皮中产生，抑制血小板聚集，调节诱导型环氧合酶的产生，并可与前列环素协同作用以减弱血栓形成过程。前列环素具有血管保护作用，保护动脉壁免受损伤引起的损伤，并保护肝脏和胃肠道的细胞。
前列环素治疗改善肺动脉高压的血流动力学。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Anna-Karin Larsson-Callerfelt et al.
Respiratory research, 14, 21-21 (2013-02-15)
Prostacyclin analogs are potent vasodilators and possess anti-inflammatory properties. However, the effect of prostacyclin on extracellular matrix (ECM) in COPD is not well known. Collagen fibrils and proteoglycans are essential ECM components in the lung and fibroblasts are key players
G J Dusting et al.
Clinical and experimental pharmacology & physiology. Supplement, 25, S34-S41 (1998-11-11)
1. Nitric oxide (NO) has important roles in physiological vasodilatation, cytotoxicity and vascular disease. Nitric oxide and prostacyclin (PGI2), both released from the endothelium, act synergistically to inhibit platelet aggregation and adhesion. These autacoids also inhibit the adhesion and migration
Seung-Jae Joo et al.
Korean circulation journal, 45(5), 378-385 (2015-09-29)
Residual platelet reactivity in patients who are taking clopidogrel is commonly measured with VerifyNow assay, which is based on the principle of light transmission aggregometry. However, to evaluate the residual platelet reactivity, it would be more accurate if the reactivity
Paola Vitale et al.
Journal of medicinal chemistry, 56(11), 4277-4299 (2013-05-09)
3-(5-Chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6), a known selective cyclooxygenase-1 (COX-1) inhibitor, was used to design a new series of 3,4-diarylisoxazoles in order to improve its biochemical COX-1 selectivity and antiplatelet efficacy. Structure-activity relationships were studied using human whole blood assays for COX-1 and
Effects of ethanol on aggregation, serotonin release, and amyloid precursor protein processing in rat and human platelets
Ehrlich D and Humpel C
Platelets, 25(1), 16-22 (2014)
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