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Merck
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文件

安全信息

P6062

Sigma-Aldrich

Protein Kinase A Inhibitor Fragment 6-22 amide

≥97% (HPLC)

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About This Item

经验公式（希尔记法）:
C80H130N28O24
CAS号:
121932-06-7
分子量:
1868.06
MDL编号:
MFCD00133792
UNSPSC代码:
12352202
PubChem化学物质编号:
329820240
NACRES:
NA.77

质量水平

200

检测方案

≥97% (HPLC)

形式

powder

储存温度

−20°C

SMILES字符串

CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)C(N)=O

InChI

1S/C80H130N28O24/c1-10-37(3)60(63(83)118)106-66(121)41(7)96-72(127)52(32-55(81)113)103-69(124)49(22-17-29-92-80(88)89)100-68(123)47(20-15-27-90-78(84)85)98-57(115)35-94-76(131)62(43(9)111)108-70(125)48(21-16-28-91-79(86)87)99-56(114)34-93-67(122)54(36-109)105-65(120)40(6)97-77(132)61(38(4)11-2)107-74(129)51(30-44-18-13-12-14-19-44)102-73(128)53(33-58(116)117)101-64(119)39(5)95-71(126)50(104-75(130)59(82)42(8)110)31-45-23-25-46(112)26-24-45/h12-14,18-19,23-26,37-43,47-54,59-62,109-112H,10-11,15-17,20-22,27-36,82H2,1-9H3,(H2,81,113)(H2,83,118)(H,93,122)(H,94,131)(H,95,126)(H,96,127)(H,97,132)(H,98,115)(H,99,114)(H,100,123)(H,101,119)(H,102,128)(H,103,124)(H,104,130)(H,105,120)(H,106,121)(H,107,129)(H,108,125)(H,116,117)(H4,84,85,90)(H4,86,87,91)(H4,88,89,92)/t37-,38-,39-,40-,41-,42+,43+,47-,48-,49-,50-,51-,52-,53-,54-,59-,60-,61-,62-/m0/s1

InChI key

VAKHFAFLRUNHLQ-PEBJKXEYSA-N

Amino Acid Sequence

Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2

应用

Protein Kinase A Inhibitor Fragment 6-22 amide has been used as a PKA inhibitor:
  • to study its effects on oocytes in two-electrode voltage clamp (TEVC) experiments
  • to study its effects on antinociception levels in mice
  • in PKA phosphorylation assay

生化/生理作用

Protein Kinase A Inhibitor Fragment 6-22 amide (PKI 6-22) is a derivative of an active portion of the heat-stable cAMP-dependent protein kinase (PKA) inhibitor (PKI). It is a potent inhibitor of PKA.

其他说明

Lyophilized from 0.1% TFA in H2O

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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Journal of cellular biochemistry, 120(8), 13783-13791 (2019-04-03)
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P P Khan et al.
General and comparative endocrinology, 181, 88-97 (2012-11-24)
Possible involvement of cyclic nucleotide dependent protein kinase (PKA) and MAP kinase (MAPK) pathways during oocyte maturation in Anabas testudineus was investigated. Pre-incubation with phosphodiesterase (PDE) inhibitor, 3-isobutyl-1-methylxanthine (IBMX), inhibited 17α, 20β-DHP-induced GVBD dose dependently. PKA inhibitor, H89 could induce
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Immobilization of proteins and enzymes on solid supports has been utilized in a variety of applications, from improved protein stability on supported catalysts in industrial processes to fabrication of biosensors, biochips, and microdevices. A critical requirement for these applications is
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Scientific reports, 9(1), 9058-9058 (2019-06-23)
Network states are often determined by modulators that alter the synaptic and cellular properties of the constituent neurons. Frequently neuromodulators act via second messengers, consequently their effects can persist. This persistence at the cellular/molecular level determines the maintenance of the
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