一般描述
该酶是糖酵解途径的一部分。同时，其在通过葡萄糖进行果糖-1,6-二磷酸（FDP）的工业生产中也很重要。其分子质量为约189kDa，并且由四个亚基组成，每个亚基的分子量为约50kDa。 最适pH为9-10，等电点为4.2。
应用
来自Sigma的酶已被用于测定根瘤菌突变株中的果糖6-磷酸。
磷酸葡萄糖异构酶（PGI）是一种对D-葡萄糖6-磷酸酯和D-果糖-6-磷酸酯相互转化至关重要的酶。PGI负责糖酵解的第二步，并参与葡萄糖生成。它在细菌和真核生物中高度保守。它可用于糖含量测定中将果糖转化为葡萄糖。该产品来源于 嗜热脂肪芽孢杆菌。
生化/生理作用
磷酸葡萄糖异构酶是一种异构酶、神经白细胞介素、自分泌运动因子以及分化和成熟的中介体。
单位定义
一个酶活性单位是指在pH 9.0、温度30 °C条件下，每分钟将1.0 μm的D-果糖-6-磷酸转化为D-葡萄糖-6-磷酸所需的酶量。
外形
含Tris缓冲液的冻干粉
警示用语：
Danger
危险声明
预防措施声明
危险分类
Resp. Sens. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
A Arias et al.
Journal of bacteriology, 137(1), 409-414 (1979-01-01)
A mutant strain of complex phenotype was selected in Rhizobium meliloti after nitrosoguanidine mutagenesis. It failed to grow on mannitol, sorbitol, fructose, mannose, ribose, arabitol, or xylose, but grew on glucose, maltose, gluconate, L-arabinose, and many other carbohydrates. Assay showed
The Kinetics and Mechanism of a Reaction Catalyzed by Bacillus stearothermophilus Phosphoglucose Isomerase.
Widjaja A, et al.
Journal of Fermentation and Bioengineering, 86(3), 324-331 (1998)
Natsuko Miura et al.
Eukaryotic cell, 11(8), 1075-1082 (2012-07-04)
Glycolytic enzymes are cytosolic proteins, but they also play important extracellular roles in cell-cell communication and infection. We used Saccharomyces cerevisiae to analyze the secretory pathway of some of these enzymes, including enolase, phosphoglucose isomerase, triose phosphate isomerase, and fructose
Sean D Schoville et al.
PloS one, 7(6), e40035-e40035 (2012-07-07)
The marine copepod Tigriopus californicus lives in intertidal rock pools along the Pacific coast, where it exhibits strong, temporally stable population genetic structure. Previous allozyme surveys have found high frequency private alleles among neighboring subpopulations, indicating that there is limited
Prashant Warang et al.
International journal of hematology, 96(2), 263-267 (2012-07-12)
Homozygous glucose phosphate isomerase (GPI) deficiency is one of the most important erythroenzymopathies causing hereditary non-spherocytic hemolytic anemia (HNSHA). We report an Indian patient with HNSHA showing 85 % reduction in GPI activity resulting from a homozygous missense replacement g.1459C
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