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P5499

Dorsomorphin

Name: Dorsomorphin
Brand: SIGMA

≥98% (HPLC), powder, AMPK inhibitor

别名:

6-[4-(2-哌啶基-1-乙氧基)苯基]-3-吡啶基-4-吡唑并[1,5-a]嘧啶, AMPK抑制剂, Compound C, Dorsomorphin

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About This Item

经验公式（希尔记法）:

C₂₄H₂₅N₅O

CAS号:

866405-64-3

分子量:

399.49

MDL编号:

MFCD08705402

UNSPSC代码:

51111800

PubChem化学物质编号:

24898658

NACRES:

NA.77

product name

Dorsomorphin, ≥98% (HPLC)

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

储存条件

protect from light

颜色

white to beige

溶解性

DMSO: >2 mg/mL (warmed)

储存温度

2-8°C

SMILES字符串

C1CCN(CC1)CCOc2ccc(cc2)-c3cnc4c(cnn4c3)-c5ccncc5

InChI

1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2

InChI key

XHBVYDAKJHETMP-UHFFFAOYSA-N

一般描述

Dorsomorphin got its name due to its ability to induce dorsoventral patterning abnormalities in zebrafish, a characteristic trait of BMP-pathway mutant embryos. Structurally, dorsomorphin is identical to compound C. Dorsomorphin induces stem cell differentiation, suggesting potential therapeutic implications for fibrodysplasia ossificans progressiva (FOP), a progressive muscle and bone disease. Besides its BMP signaling inhibition, dorsomorphin also hinders the vascular endothelial growth factor (VEGF) type 2 receptor (FLK1/KDR) and disrupts angiogenesis during zebrafish development.

应用

Dorsomorphin可用于：

用作磷酸腺苷激活蛋白激酶(APK)的抑制剂，寻找白藜芦醇对3T3-L1（小鼠脂肪细胞系）细胞中脂质移动的影响
用作AMPK抑制剂，指示AMPK/mTOR（哺乳动物雷帕霉素靶蛋白）通路参与LRG（利拉鲁肽）诱导的自噬
在诱导步骤中，利用胚胎干细胞(ES)培养基，将弗里德的共济失调(FRDA)和诱导多能干细胞(iPSC)向经球和神经元体外分化

生化/生理作用

Dorsomorphin是骨形态生成蛋白（BMP）信号传导的选择性抑制剂。已有研究发现它能够抑制胚胎形成所需的BMP信号，并显著促进人多能干细胞（hPSC）的神经分化。 Dorsomorphin还可作为AMPK（AMP活化蛋白激酶）的有效的、选择性、可逆性和ATP竞争性抑制剂；当存在5μM的ATP且不存在AMP时，Ki = 109 nM）。

特点和优势

《受体分类和信号转导》手册的 AMPK 页面有该化合物的介绍。想要浏览手册的其他页面，请单击此处。

该化合物是激酶磷酸酶生物学研究推荐产品。点击此处，查看更多激酶磷酸酶生物学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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访问文档库

GLP-1 analogue improves hepatic lipid accumulation by inducing autophagy via AMPK/mTOR pathway

He Qin, et al.

Biochemical and Biophysical Research Communications, 476(4), 196-203 (2016)

Role of mismatch repair enzymes in GAA-TTC triplet-repeat expansion in Friedreich's ataxia induced pluripotent stem cells (iPSCs)

Du J, et al.

Test, jbc-M112 (2012)

Bone morphogenetic protein 2 regulates cell-cell communication by down-regulating connexin43 expression in luteinized human granulosa cells.

Yan-Ting Wu et al.

Molecular human reproduction, 23(3), 155-165 (2016-12-18)

Does bone morphogenetic protein 2 (BMP2) regulate connexin43 (Cx43) and modulate cell-cell communication in luteinized human granulosa cells? BMP2 decreases gap junction intercellular communication (GJIC) of luteinized human granulosa cells by down-regulating Cx43 expression through an activin receptor-like kinase (ALK)2/ALK3-mediated

TRPC6 is required for hypoxia-induced basal intracellular calcium concentration elevation, and for the proliferation and migration of rat distal pulmonary venous smooth muscle cells.

Qingjie Wang et al.

Molecular medicine reports, 13(2), 1577-1585 (2016-01-01)

Hypoxia induces pulmonary vasoconstriction and reconstruction in the pulmonary arteries and pulmonary veins (PVs), and elevation of intracellular calcium concentration ([Ca2+]i) is a primary factor of these processes. In the present study, the role of transient receptor potential cation channels

Laminins, via heparan sulfate proteoglycans, participate in zebrafish myotome morphogenesis by modulating the pattern of Bmp responsiveness.

Morgane Dolez et al.

Development (Cambridge, England), 138(1), 97-106 (2010-12-01)

In zebrafish, Hedgehog-induced Engrailed expression defines a muscle fibre population that includes both slow and fast fibre types and exhibits an organisational role on myotome and surrounding tissues, such as motoneurons and lateral line. This Engrailed-positive population is restricted in

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