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Merck
CN

P5296

CTOP

≥97% (HPLC)

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选择尺寸

关于此项目

经验公式（希尔记法）:
C50H67N11O11S2
化学文摘社编号:
103429-31-8
分子量:
1062.26
NACRES:
NA.77
PubChem Substance ID:
329820226
UNSPSC Code:
12352200
MDL number:
MFCD00076708

主要文件

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产品名称

CTOP, ≥97% (HPLC)

InChI key

PZWWYAHWHHNCHO-FGHAYEPSSA-N

SMILES string

C[C@@H](O)[C@H](NC(=O)[C@H]1NC(=O)[C@@H](NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CSSC1(C)C)NC(=O)[C@H](N)Cc5ccccc5)[C@@H](C)O)C(N)=O

InChI

1S/C50H67N11O11S2/c1-26(62)39(42(53)65)59-49(72)41-50(3,4)74-73-25-38(58-43(66)33(52)21-28-11-6-5-7-12-28)47(70)56-36(22-29-16-18-31(64)19-17-29)45(68)57-37(23-30-24-54-34-14-9-8-13-32(30)34)46(69)55-35(15-10-20-51)44(67)60-40(27(2)63)48(71)61-41/h5-9,11-14,16-19,24,26-27,33,35-41,54,62-64H,10,15,20-23,25,51-52H2,1-4H3,(H2,53,65)(H,55,69)(H,56,70)(H,57,68)(H,58,66)(H,59,72)(H,60,67)(H,61,71)/t26-,27-,33-,35+,36+,37-,38+,39+,40+,41-/m1/s1

assay

≥97% (HPLC)

form

powder

UniProt accession no.

Q64387

storage temp.

−20°C

Quality Level

100

Gene Information

mouse ... Pnoc(18155)

Application

CTOP已用于：
  • 研究CTOP对小鼠和大鼠的抗焦虑作用。
  • 研究μ-阿片受体拮抗剂CTOP对牛乳源性LF（BLF）镇痛作用的影响。
  • 确定μ-阿片受体是否与5-羟色胺（5-HT1A）受体协同作用，以调节在高架T迷宫（ETM）中产生的行为。

Biochem/physiol Actions

μ阿片受体的选择性配体。
D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2（CTOP）在体内以剂量依赖性方式抑制急性吗啡诱导的运动过度和吗啡的镇痛作用。

General description

D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2（CTOP）是一种选择性的环状μ-阿片受体拮抗剂。

Other Notes

生长抑素类似物

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN5321
BCCD2654
BCBT1953
BCBL8678V
BCBL8678

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Cooperative regulation of anxiety and panic-related defensive behaviors in the rat periaqueductal grey matter by 5-HT1A and ?-receptors.
Roncon CM
Journal of Psychopharmacology, 27(12), 1141-1148 (2013)
G T C Wong et al.
Acta anaesthesiologica Scandinavica, 54(4), 510-518 (2009-11-03)
Ischemic pre- or post-conditioning of the heart has been shown to involve opioid receptors. Remifentanil, an ultra-short-acting selective mu opioid receptor agonist in clinical use, pre-conditions the rat heart against ischemia-reperfusion injury. This study investigates whether remifentanil post-conditioning is also
Céline Heinl et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(46), 16748-16756 (2011-11-18)
In addition to analgesia, opioids may also produce paradoxical pain amplification [opioid-induced hyperalgesia (OIH)] either on abrupt withdrawal or during continuous long-term application. Here, we assessed antinociceptive and pronociceptive effects of three clinically used opioids at C-fiber synapses in the
Central effects of the potent and highly selective mu opioid antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) in mice.
Gulya K
European Journal of Pharmacology, 150(3), 355-360 (1988)
Andrew C Eschenroeder et al.
Glia, 60(1), 125-136 (2011-10-18)
Although the classical function of myelin is the facilitation of saltatory conduction, this membrane and the oligodendrocytes, the cells that make myelin in the central nervous system (CNS), are now recognized as important regulators of plasticity and remodeling in the
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