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安全信息

P5234

Sigma-Aldrich

Purvalanol B

≥97% (HPLC), solid

别名:

(2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol, NG 95

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About This Item

经验公式（希尔记法）:
C20H25ClN6O3
CAS号:
212844-54-7
分子量:
432.90
MDL编号:
MFCD04118312
UNSPSC代码:
12352200
PubChem化学物质编号:
329820218
NACRES:
NA.77

质量水平

100

方案

≥97% (HPLC)

表单

solid

溶解性

DMSO: soluble 37 mg/mL
H2O: insoluble

运输

dry ice

储存温度

−20°C

SMILES字符串

CC(C)[C@H](CO)Nc1nc(Nc2ccc(C(O)=O)c(Cl)c2)c3ncn(C(C)C)c3n1

InChI

1S/C20H25ClN6O3/c1-10(2)15(8-28)24-20-25-17(16-18(26-20)27(9-22-16)11(3)4)23-12-5-6-13(19(29)30)14(21)7-12/h5-7,9-11,15,28H,8H2,1-4H3,(H,29,30)(H2,23,24,25,26)/t15-/m0/s1

InChI key

ZKDXRFMOHZVXSG-HNNXBMFYSA-N

生化/生理作用

Purvalanol B is a cyclin-dependent; 2,6,9-substituted kinase inhibitor.

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCBH6844V
BCBF4157V
BCBC3680V
BCBC3680
BCBC0748

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  1. How does the storage temperature relate to shipping conditions?

    The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.

  2. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  3. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  4. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  5. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  6. At what concentration is Product P5234, Purvalanol B, soluble in DMSO?

    We have not necessarily tested a maximum value for solubility of Product P5234, Purvalanol B, in DMSO. However, one publication indicates preparation of a 100 mM stock solution in DMSO.  Holton, S., et al., Structures of P. falciparum PfPK5 Test the CDK Regulation Paradigm and Suggest Mechanisms of Small Molecule Inhibition. Structure, 11(11), 1329-1337 (2003).

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Voin Petrovic et al.
Nutrients, 10(4) (2018-04-06)
The use of garlic and garlic-based extracts has been linked to decreased incidence of cancer in epidemiological studies. Here we examine the molecular and cellular activities of a simple homemade ethanol-based garlic extract (GE). We show that GE inhibits growth
Voin Petrovic et al.
Analytical biochemistry, 523, 10-16 (2017-02-09)
The Multiplexed Inhibitor Bead (MIB) assay is a previously published quantitative proteomic MS-based approach to study cellular kinomes. A rather extensive procedure, need for multiple custom-made kinase inhibitors and an inability to re-use the MIB-columns, has limited its applicability. Here
Alison M Kurimchak et al.
Science signaling, 13(619) (2020-02-20)
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with few effective, targeted therapies. HGSOC tumors exhibit genomic instability with frequent alterations in the protein kinome; however, only a small fraction of the kinome has been therapeutically targeted
Matthew B Lipner et al.
JCI insight, 5(8) (2020-03-28)
Over 55,000 people in the United States are diagnosed with pancreatic ductal adenocarcinoma (PDAC) yearly, and fewer than 20% of these patients survive a year beyond diagnosis. Chemotherapies are considered or used in nearly every PDAC case, but there is
Alison M Kurimchak et al.
Molecular cancer research : MCR, 17(8), 1721-1734 (2019-05-03)
Mutation or deletion of Neurofibromin 1 (NF1), an inhibitor of RAS signaling, frequently occurs in epithelial ovarian cancer (EOC), supporting therapies that target downstream RAS effectors, such as the RAF-MEK-ERK pathway. However, no comprehensive studies have been carried out testing
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