推荐产品
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
8G2, monoclonal
表单
buffered aqueous solution
种属反应性
rat, bovine, pig, mouse, rabbit, feline, human
技术
immunohistochemistry: suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.5-1.0 μg/mL using total cell extract from rat PC12 cells
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... PRPH(5630)
mouse ... Prph(19132)
rat ... Prph(24688)
一般描述
Monoclonal Anti-Peripherin (mouse IgG1 isotype) is derived from the 8G2 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mice immunized with the full-length recombinant rat peripherin. Peripherin was originally identified as a neuronal intermediate filament protein-(IF) is thought to be expressed only in the peripheral nervous system (PNS).
Peripherin is an intermediate filament protein. It is expressed in peripheral and enteric neurons. The gene encoding this protein is localized on rat chromosome 7.
免疫原
full-length recombinant rat peripherin.
应用
Anti-Peripherin antibody, Mouse monoclonal has been used in:
- immunohistochemistry
- western blotting
- enzyme linked immunosorbent assay (ELISA)
- immunofluorescence staining
生化/生理作用
Peripherin is upregulated during pheochromocytoma PC12 cell differentiation. Later studies have detected peripherin also in certain central nervous system (CNS) neurons.
eripherin has been linked with axonal extension and regeneration of nerve fibers. It also has a role in neurite outgrowth propagation. Peripherin is a substrate of protein kinase B/Akt. Phosphorylation of this protein is induced after nerve injury.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Identification of peripherin as a Akt substrate in neurons.
Konishi H
The Journal of Biological Chemistry (2007)
New insights into peripherin expression in cochlear neurons.
Lallemend F
Neuroscience (2007)
Peripherin and ATF3 genes are differentially regulated in regenerating and non-regenerating primary sensory neurons.
Reid AJ
Brain Research (2010)
Suppression of Extensive Neurofilament Phosphorylation Rescues alpha-Internexin/Peripherin-Overexpressing PC12 Cells from Neuronal Cell Death
Lee WC, et al.
PLoS ONE, 7(8), e43883-e43883 (2012)
Rania Magadmi et al.
Frontiers in cellular neuroscience, 13, 262-262 (2019-07-06)
Neuroimmune interactions are important in the pathophysiology of many chronic inflammatory diseases, particularly those associated with alterations in sensory processing and pain. Mast cells and sensory neuron nerve endings are found in areas of the body exposed to the external
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