P4904
β-乙酰基-γ-O-十六烷基-L-α-磷脂酰胆碱 水合物
≥98%
别名:
1-O-棕榈基-2-乙酰基-sn-甘油-3-磷酸胆碱 一水合物, 1-十六烷基-2-乙酰基-sn-甘油-3-磷酸胆碱, 2-乙酰基-1-十六烷基-sn-甘油-3-磷酸胆碱, 3-sn-磷脂酰胆碱，1-十六烷基-2-乙酰基, PAF(C16), 血小板活化因子
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所有图片(1)
About This Item
经验公式（希尔记法）:
C26H54NO7P · xH2O
CAS号:
分子量:
523.68 (anhydrous basis)
Beilstein:
3574588
MDL编号:
UNSPSC代码:
12352211
PubChem化学物质编号:
NACRES:
NA.77
质量水平
检测方案
≥98%
形式
powder
储存温度
−20°C
SMILES字符串
O.CCCCCCCCCCCCCCCCOC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(C)=O
InChI
1S/C26H54NO7P.H2O/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5;/h26H,6-24H2,1-5H3;1H2/t26-;/m1./s1
InChI key
HFMSDOHEENWULV-UFTMZEDQSA-N
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应用
β-乙酰基-γ-O-十六烷基-L-α-磷脂酰胆碱已用于：
- 研究其对马肺泡巨噬细胞和血液中性粒细胞中吞噬活性及超氧阴离子产生的影响
- 在体外研究其对顺铂诱导的人黑色素瘤细胞系细胞死亡的保护作用
- 测定其对大鼠宫颈成熟和白细胞浸润的影响
生化/生理作用
β-乙酰基-γ-O-十六烷基-L-α-磷脂酰胆碱又称血小板激活因子（PAF），是一种磷脂，也是促炎脂质介质。它作为G蛋白偶联血小板活化因子（PAF）受体的配体，参与气道收缩、低血压、血小板活化和血管通透性增加等生物学过程。PAF由血小板、中性粒细胞、内皮细胞和单核/巨噬细胞等多种细胞释放。由于PAF乙酰水解酶代谢快，产量低，血液中的PAF水平低。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Damien Garrido et al.
Frontiers in veterinary science, 4, 226-226 (2018-01-13)
Lipid mediators are known to play important roles in the onset and resolution phases of the inflammatory response in mammals. The phospholipid platelet-activating factor (PAF) is a pro-inflammatory lipid mediator which participates in vascular- and innate immunity-associated processes by increasing
Platelet-activating factor.
S M Prescott et al.
The Journal of biological chemistry, 265(29), 17381-17384 (1990-10-15)
S Grassi et al.
Neuroscience, 94(2), 549-559 (1999-12-01)
In rat brainstem slices, we investigated the interaction between platelet-activating factor and group I metabotropic glutamate receptors in mediating long-term potentiation within the medial vestibular nuclei. We analysed the N1 field potential wave evoked in the ventral portion of the
Luis Alexandre Muehlmann et al.
Research in veterinary science, 93(1), 393-397 (2011-08-09)
Phagocytosis exerted by alveolar macrophages and neutrophils is crucial in the clearance of exogenous particles deposited in the airways. Therefore, substances that activate these phagocytes in the airways can exert important effects on the particle clearance rate. PAF, particularly, was
Katarina Mariann Jørgensen et al.
Archives of dermatological research, 302(3), 221-227 (2009-12-31)
Platelet activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is known to be present in excess in psoriatic skin, but its exact role is uncertain. In the present study we demonstrate for the first time the role of group VI PLA(2) in PAF-induced arachidonic
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