P4904
β-乙酰基-γ-O-十六烷基-L-α-磷脂酰胆碱 水合物
≥98%
别名:
1-O-棕榈基-2-乙酰基-sn-甘油-3-磷酸胆碱 一水合物, 1-十六烷基-2-乙酰基-sn-甘油-3-磷酸胆碱, 2-乙酰基-1-十六烷基-sn-甘油-3-磷酸胆碱, 3-sn-磷脂酰胆碱，1-十六烷基-2-乙酰基, PAF(C16), 血小板活化因子
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所有图片(1)
About This Item
经验公式（希尔记法）:
C26H54NO7P · xH2O
CAS号:
分子量:
523.68 (anhydrous basis)
Beilstein:
3574588
MDL编号:
UNSPSC代码:
12352211
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥98%
表单
powder
储存温度
−20°C
SMILES字符串
O.CCCCCCCCCCCCCCCCOC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(C)=O
InChI
1S/C26H54NO7P.H2O/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5;/h26H,6-24H2,1-5H3;1H2/t26-;/m1./s1
InChI key
HFMSDOHEENWULV-UFTMZEDQSA-N
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应用
β-乙酰基-γ-O-十六烷基-L-α-磷脂酰胆碱已用于：
- 研究其对马肺泡巨噬细胞和血液中性粒细胞中吞噬活性及超氧阴离子产生的影响
- 在体外研究其对顺铂诱导的人黑色素瘤细胞系细胞死亡的保护作用
- 测定其对大鼠宫颈成熟和白细胞浸润的影响
生化/生理作用
β-乙酰基-γ-O-十六烷基-L-α-磷脂酰胆碱又称血小板激活因子（PAF），是一种磷脂，也是促炎脂质介质。它作为G蛋白偶联血小板活化因子（PAF）受体的配体，参与气道收缩、低血压、血小板活化和血管通透性增加等生物学过程。PAF由血小板、中性粒细胞、内皮细胞和单核/巨噬细胞等多种细胞释放。由于PAF乙酰水解酶代谢快，产量低，血液中的PAF水平低。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
R N Pinckard et al.
Journal of leukocyte biology, 59(2), 219-228 (1996-02-01)
Alkyl-PAF induced two components of polymorphonuclear leukocyte (PMN) priming for enhanced fMLP- and rC5a-induced superoxide anion (O2-) production. Component A priming had a shallow, linear alkyl-PAF concentration-response slope (10 pM-1 nM), and component B priming had a significantly steeper concentration-response
T Hiran et al.
Prostaglandins & other lipid mediators, 66(4), 305-315 (2002-01-12)
Platelet-activating factor (PAF) is an early product of the inflammatory environment, influencing development and resolution of inflammation. Its production is greater in neutrophils and macrophages, which predominantly synthesize 1-alkyl sn-2 acetyl glycerophosphocholine (GPC) than in nongranulocytes (B cells and endothelial
Naoki Okumura et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 22(5), 347-352 (2006-11-02)
The aim of this study was to examine the levels of platelet-activating factor (PAF) and lyso-PAF in tears from experimental animals developing allergic conjunctivitis (AC). AC was induced in guinea pigs by application of ovalbumin in eye drops. Tear samples
Adriana Vieira-de-Abreu et al.
International immunopharmacology, 5(13-14), 1966-1974 (2005-11-09)
New therapeutic approaches for the treatment of allergic diseases can be aided by the development of agents capable of regulating eosinophilic leukocytes. Here, we evaluated the anti-allergic properties of a crude extract of the Brazilian bromeliaceae Nidularium procerum, focusing on
Weirong Fang et al.
Journal of neurochemistry, 128(5), 662-671 (2013-10-30)
The blood-brain barrier (BBB) greatly limits the efficacy of many neuroprotective drugs' delivery to the brain, so improving drug penetration through the BBB has been an important focus of research. Here we report that platelet activating factor (PAF) transiently opened
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