所有图片(1)
About This Item
经验公式（希尔记法）:
C19H24N2O2
CAS号:
分子量:
312.41
Beilstein:
761557
EC 号:
MDL编号:
UNSPSC代码:
51452701
PubChem化学物质编号:
NACRES:
NA.85
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表单
powder or crystals
抗生素抗菌谱
parasites
作用机制
cell membrane | interferes
储存温度
−20°C
SMILES字符串
O=C1CN(CC2N1CCc3ccccc23)C(=O)C4CCCCC4
InChI
1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2
InChI key
FSVJFNAIGNNGKK-UHFFFAOYSA-N
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应用
吡喹酮是一种强效驱虫剂，可用于对抗血吸虫和多种绦虫的侵扰。它用于研究电压门控Ca2+ 通道，是一种潜在的小分子神经源性药物.
生化/生理作用
吡喹酮会增加被盖层对 Ca2+的渗透性，从而诱发的肌肉收缩和死亡。吡喹酮会导致血吸虫被盖层空泡的形成和分解。它对成年蠕虫比对幼年成年更有效。它会抑制葡萄糖吸收，从而降低糖水平，刺激乳酸释放。吡喹酮是一种强效驱虫剂，可用于对抗寄生扁虫（吸虫和绦虫）。最近的研究表明，吡喹酮能够与电压门控Ca2+ 通道亚基的变体以及肌动蛋白（某些 Ca2+通道的组分）结合。
其他说明
1g,5g,25g
保存于密闭容器内，置于干燥通风处。
危险声明
预防措施声明
危险分类
Aquatic Chronic 3
储存分类代码
11 - Combustible Solids
WGK
WGK 1
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Yuxiang Dong et al.
Bioorganic & medicinal chemistry letters, 20(8), 2481-2484 (2010-03-23)
Six amide and four urea derivatives of praziquantel were synthesized and tested for antischistosomal activity against juvenile and adults stages of Schistosoma mansoni in infected mice. Only one of these had significant activity against adult worms, but, unlike praziquantel, six
R J Martin et al.
Parasitology, 114 Suppl, S111-S124 (1997-01-01)
This paper reviews sites of action of anthelmintic drugs including: (1) levamisole and pyrantel, which act as agonists at nicotinic acetylcholine receptors of nematodes; (2) the avermectins, which potentiate or gate the opening of glutamategated chloride channels found only in
Dan Zhang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(44), 15983-15995 (2011-11-04)
There is intense interest in developing methods to regulate proliferation and differentiation of stem cells into neuronal fates for the purposes of regenerative medicine. One way to do this is through in vivo pharmacological engineering using small molecules. However, a
Fiona Ronketti et al.
Bioorganic & medicinal chemistry letters, 17(15), 4154-4157 (2007-06-09)
Several analogues of the potent anthelmintic praziquantel were prepared with variation in the aromatic ring. The biological activity of these analogues was evaluated and compared against known analogues. Amination of the ring was tolerated while other variations were not. These
Malay Patra et al.
Journal of medicinal chemistry, 56(22), 9192-9198 (2013-11-14)
In vitro metabolic behavior was investigated for two chromium tricarbonyl derivatives of the antischistosomal drug praziquantel (PZQ) with the formula (η(6)-PZQ)Cr(CO)3 (1 and 2), by use of human liver microsomes. The metabolic profiles of the derivatives differ significantly. The optically
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