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安全信息

P4623

Sigma-Aldrich

Anti-phospho-Interferon-α Receptor Type I (pSer535/pSer539) Subunit 1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

别名:

Anti-phospho-IFNα Receptor Type I (pSer535/pSer539) Subunit 1, Anti-phospho-IFNARI

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About This Item

MDL编号:
MFCD07370443
UNSPSC代码:
12352203
NACRES:
NA.46

生物来源

rabbit

质量水平

100

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

种属反应性

rat, mouse, bovine, human

技术

western blot: 1:1,000 using using FLAG® immunoprecipitates from HEK 293 cells transfected with Mock, IFNAR1 wild type, or IFNAR1 S535A and S539A mutants

UniProt登记号

P17181

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

phosphorylation (pSer535/pSer539)

基因信息

human ... IFNAR1(3454)
mouse ... Ifnar1(15975)
rat ... Ifnar1(288264)

免疫原

synthetic phosphopeptide corresponding to the amino acid residues surrounding the human phospho-interferon-α receptor type I (pSer535/pSer539) subunit 1.

生化/生理作用

Type I interferons (IFNα, IFNβ and IFNω) are pleotropic cytokines that mediate their cellular activities by binding to specific Type I IFN receptors. The functions of IFNα/ IFNα Receptor Type I axis include antiproliferative, antiviral and immunomodulatory activities.

外形

Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA, and 50% glycerol.

法律信息

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

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分析证书(COA)

Lot/Batch Number
025K0909

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P Domanski et al.
Cytokine & growth factor reviews, 7(2), 143-151 (1996-08-01)
The type-I interferon receptor is a multisubunit receptor of the cytokine receptor superfamily. The production of specific monoclonal antibodies against the receptor and the cloning of different receptor subunits have contributed to understanding the type-I interferon receptor structure and function.
L C Platanias et al.
The Journal of biological chemistry, 271(39), 23630-23633 (1996-09-27)
All Type I interferons (IFNalpha, IFNbeta, IFNomega) bind to the Type I IFN receptor (IFNR) and elicit a common set of signaling events, including activation of the Jak/Stat and IRS pathways. However, IFNbeta selectively induces the association of the alpha

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